Two new kinds of fluorocarbon phospholipids with choline and phosphate as polar head group were synthesized. Both compounds can form liposomes under dispersion by sonication or injection. The size of liposomes with choline group is in the range of 32-37 nm based on the measurements of electron microscopy and dynamic light scattering, but the light scattering result pointed out that the size of liposomes with phosphate group is larger and increased with increasing pH value of the system. Fluorocarbon liposomes, same as conventional hydrogen analogs, possess the ability to incorporate the water-sol. substrates like bromothymol blue. But the liposome made from fluorocarbon compounds are more clear than those of hydrocarbon ones. There is a turning point at 53?in the plot of fluorescence intensity of ANS (antracenesulfonic acid sodium salt) which incorporated into fluorocarbon liposome via temperature, this result agreed with the reported results that the phase transition of fluorocarbon vesicles take place at higher temperature and the thermal effect is small.

Key words: PHOSPHORIC ACID P, LIPOSOME, ELECTRON-MICROSCOPIC ANALYSIS, CHOLINE, PHASE TRANSFORMATION, PHOSPHOLIPID, LIGHT SCATTERING, CLATHRATES, FLUOROCARBON