Acta Chimica Sinica ›› 2005, Vol. 63 ›› Issue (18): 1661-1665. Previous Articles     Next Articles

Original Articles

脱乙酰壳多糖抑制真菌生长的构效关系

杨典洱,林晓怡,向本琼,杨照罡,王海龙,魏群*   

  1. (北京师范大学生化与分子生物学系 北京市重点实验室 北京 100875)
  • 投稿日期:2005-01-17 修回日期:2005-05-23 发布日期:2010-12-10
  • 通讯作者: 魏群

Structure-Function Relationship of Chitosan against Phytopathogenic Fungi

YANG Dian-Er, LIN Xiao-Yi, XIANG Ben-Qiong, YANG Zhao-Gang, WANG Hai-Long, WEI Qun*   

  1. (College of Life Sciences, Beijing Normal University, Beijing 100875)
  • Received:2005-01-17 Revised:2005-05-23 Published:2010-12-10
  • Contact: WEI Qun

The objective of this study was to investigate the relation between anti-fungal activity and their chemical structure (DA, degree of acetylation or DP, degree of polymerization) of chitosans. 12 different chemical structure chitosans with well characterized DA and DP were tested against three different phytopathogenic fungi (Fusarium solani, Fusarium graminearum and Ustilago maydis) respectively. MIC (minimum inhibitory concentration) of every chitosan against every fungus was determined with micro plate reader, and then these MIC data were analyzed and correlated with their chemical structure (DA or DP). The results showed that anti-fungal activity MIC of every chitosan was different against even the same fungus, and then also against different fungi; but it was increased with decreasing both DP and DA of chitosan.

Key words: chitosan, anti-fungal activity, Fusarium solani, Fusarium graminearum, Ustilago maydis