Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (8): 806-810. Previous Articles     Next Articles

Original Articles

柔红霉素修饰的纳米金电极的制备及其对DNA检测

郑华,胡劲波*,李启隆   

  1. (北京师范大学化学系 北京 100875)
  • 投稿日期:2005-07-01 修回日期:2005-12-26 发布日期:2006-04-25
  • 通讯作者: 胡劲波

Preparation of Daunomycin Modified Nano Gold Electrode and, Its Application to Detection of DNA

ZHENG Hua, HU Jing-Bo*, LI Qi-Long   

  1. (Department of Chemistry, Beijing Normal University, Beijing 100875)
  • Received:2005-07-01 Revised:2005-12-26 Published:2006-04-25
  • Contact: HU Jing-Bo

The modification of gold electrode with gold nanoparticles by chemical adsorption of 1,6-hexanedithiol was achieved. The preparation process and activity of this interface were characterized with voltammetry, UV-Vis spectroscopy and electrochemical impedance spectroscopy. The modified electrode was used to detect DNA and the damage of DNA, with the detection limit of DNA to be 1.2×10-9 mol/L. This method is sensitive and convenient.

Key words: gold nanoparticle, daunomycin, DNA