Synthesis and Studies on DNA-binding of a New Nickel Complex with Pyrrole and Polyamine

Acta Chimica Sinica ›› 2010, Vol. 68 ›› Issue (06): 481-486. Previous Articles Next Articles

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一种新的吡咯多胺镍配合物的合成及其与DNA的作用研究

邹敏, 刘叔文, 周春琼

(南方医科大学药学院广州 510515)

投稿日期:2009-09-04 修回日期:2009-11-09 发布日期:2010-03-28
通讯作者: 周春琼 E-mail:huagongzhoucq@163.com
基金资助:
广东省自然科学基金

Synthesis and Studies on DNA-binding of a New Nickel Complex with Pyrrole and Polyamine

Zou Min Liu Shuwen Zhou Chunqiong

(School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515)

Received:2009-09-04 Revised:2009-11-09 Published:2010-03-28

Abstract

A new nickel complex of pyrrole-polyamine had been synthesized and its structure had been characterized by MS, ¹H NMR, IR, molar conductance and elementary analysis. CT DNA-binding of nickel complex had been investigated using UV spectra, fluorescent spectra and viscosity. The results have proved that the mode of binding of nickel complex to CT DNA is the intercalative mode. The complex can completely translate supercoil DNA into the nicked DNA between 50 and 55 ℃. The complex has antitumor activity on HepG2, a liver tumor derived cell line.

Key words: pyrrole, polyamine, nickel complex, DNA, antitumor activity

CLC Number:

0614.81+2

Cite this article

JU Min, LIU Shu-Wen, ZHOU Chun-Qiong. Synthesis and Studies on DNA-binding of a New Nickel Complex with Pyrrole and Polyamine[J]. Acta Chimica Sinica, 2010, 68(06): 481-486.

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一种新的吡咯多胺镍配合物的合成及其与DNA的作用研究

Synthesis and Studies on DNA-binding of a New Nickel Complex with Pyrrole and Polyamine

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