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Acta Chimica Sinica ›› 2010, Vol. 68 ›› Issue (08): 788-792. Previous Articles     Next Articles

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3-取代苯氧甲基-4-氨基-1,2,4-三唑-5-硫酮席夫碱的合成、结构表征和生物活性研究

孙晓红*,1，白燕1，刘源发2，陈邦2   

  1. (1西北大学化工学院化学研究所 西安 710069)
    (2西北大学化学系 西安 710069)
  • 投稿日期:2009-10-10 修回日期:2009-11-23 发布日期:2009-12-30
  • 通讯作者: 孙晓红 E-mail:xhsun888@sohu.com

Synthesis, Structure and Biological Activities of 3-Substituted Phenoxymethyl-4-amino-1,2,4-triazol-5-thione Schiff Bases

Sun Xiaohong*,1 Bai Yan1 Liu Yuanfa2 Chen Bang2   

  1. (1 College of Chemical Engineering, Chemical Research Institute, Northwest University, Xi an 710069)
    (2Department of Chemistry, Northwest University, Xi an 710069)
  • Received:2009-10-10 Revised:2009-11-23 Published:2009-12-30
  • Contact: SUN Xiao-Hong E-mail:xhsun888@sohu.com

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Five 4-amino-4,5-dihydro-3-(substituted phenoxymethyl)-1,2,4-triazole-5-thione Schiff bases were synthesized by 4-amino-4,5-dihydro-3-(substituted phenoxymethyl)-1,2,4-triazole-5-thione and 4-fluorobenzaldehyde with acetic acid as a catalyst and solvent. The chemical structures of the compounds have been confirmed by 1H NMR, IR and elemental analysis. Their biological activities were investigated and the results showed that all of the compounds exhibited excellent fungicidal activities.

Key words: triazole, Schiff base, synthesis, biological activity