The resorcincalix[4]arene derivative has been synthesized and studied as a sensitive material for the determination of dopamine in liquid through a piezoelectric quartz crystal (PQC) sensor. The PQC- coated resorcincalix[4]arene is highly selective for dopamine in comparison with ascorbic acid. The new selectivity dimension is attributed to host-guest interactions between resorcincalix[4]arene and dopamine. The PQC is used for monitoring of dopamine in liquid at phosphate buffer (pH = 7.40) with fast response time, good sensitivity and reproducibility. It exhibits a linear response in the range 3.5- 500 μg/g of dopamine.

Key words: BENZENEDIOL P, calixarene, SENSORS, DOPAMINE