Acta Chimica Sinica ›› 1993, Vol. 51 ›› Issue (11): 1133-1138. Previous Articles     Next Articles

Original Articles

四川轮环藤根中两种海岛轮环藤-N-氧化物的分离鉴定

赖盛;赵同芳;王宪楷;志津里芳一;山村庄亮   

  1. 华西医科大学药学院;日本庆应大学理工学部
  • 发布日期:1993-11-15

Two novel insularine-N-oxides from the roots of cyclea sutchuenensis gagnep

LAI SHENG;ZHAO TONGFANG;WANG XIANKAI;ZHI JINLIFANGYI;SHAN CUNZHUANGLIANG   

  • Published:1993-11-15

Two novel insularine-N-oxides, insularine-2b-N-oxide (I) and insularine-2'b-N-oxide (II), were isolated along with insularine and insulanoline from the roots of C. sutchuenensis indigenous only to China. Their structures have been elucidated on the basis of spectral anal. and confirmed by chem. correlation with insularine. Both I and II are rare examples of naturally occurring head-to-tail bisbenzylisoquinoline N-oxides. Additional, the 1H and 13C NMR spectral data of insulanoline were first reported and assigned in detail. Insulanoline showed significant inhibitory activity against human colon adenocarcinoma.

Key words: SEPARATION, C13 NMR SPECTROMETRY, BISBENZYL ISOQUINOLINE ALKALOID, PROTON MAGNETIC RESONANCE SPECTROMETRY, ANTINEOPLASTIC ACTIVITY

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