The preparation of (9-tert-butoxycarbonylaminoacycloxymethyl) fluorene-2-acetamidobenzhydryl resin and its application to solid-phase protected peptide synthesis

Acta Chimica Sinica ›› 1988, Vol. 46 ›› Issue (11): 1145-1147. Previous Articles Next Articles

Original Articles

(9-叔丁氧羰氨酰基氧甲基)芴-2-乙酰二苯甲胺树脂的制备及其在固相合成保护肽段中的应用

刘寅曾;陈金泰;褚季瑜;丁少华;严秉淳

中国科学院上海有机化学研究所;华东化工学院

发布日期:1988-11-15

The preparation of (9-tert-butoxycarbonylaminoacycloxymethyl) fluorene-2-acetamidobenzhydryl resin and its application to solid-phase protected peptide synthesis

LIU YINZENG;CHEN JINTAI;CHU JIYU;DING SHAOHUA;YAN BINGCHUN

Published:1988-11-15

Abstract

The title support for the synthesis of protected peptide fragments on solid-phase was prepared Protected heptapeptide Me3CO2C-Val-Val-Ser(OCH2Ph)-His(Tos)-Phe-Asn-Lys(CO2CH2Ph)-OH (Tos = tosyl), corresponding to the sequence 1-7 of rat-transforming growth factor-a was synthesized on this new support with a total yield of 50%.

Key words: BUTOXY GROUP, CONSERVATION, AMINO GROUP, SOLIDPHASE SYNTHESIS, PEPTIDE, CARBONYL GROUP, RESIN, ACYLOXY, ACETANILIDE P, FLUORENE

CLC Number:

O626
Q5

Cite this article

LIU YINZENG;CHEN JINTAI;CHU JIYU;DING SHAOHUA;YAN BINGCHUN. The preparation of (9-tert-butoxycarbonylaminoacycloxymethyl) fluorene-2-acetamidobenzhydryl resin and its application to solid-phase protected peptide synthesis[J]. Acta Chimica Sinica, 1988, 46(11): 1145-1147.

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(9-叔丁氧羰氨酰基氧甲基)芴-2-乙酰二苯甲胺树脂的制备及其在固相合成保护肽段中的应用

The preparation of (9-tert-butoxycarbonylaminoacycloxymethyl) fluorene-2-acetamidobenzhydryl resin and its application to solid-phase protected peptide synthesis

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