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Acta Chimica Sinica ›› 2005, Vol. 63 ›› Issue (13): 1225-1230. Previous Articles     Next Articles

Original Articles

配合物[Pd(L-tyr)2]•0.5H2O的晶体结构、稳定性及其与DNA作用研究

高恩君*1，李浩洋1，刘祁涛2   

  1. (1沈阳化工学院配位化学研究室 沈阳 110142)
    (2辽宁大学化学科学与工程学院 沈阳 110036)
  • 投稿日期:2004-08-06 修回日期:2005-03-04 发布日期:2010-12-10
  • 通讯作者: 高恩君

Study on Crystal Structure, Stability and the Interaction of Complex [Pd(L-tyr)2]•0.5H2O with DNA

GAO En-Jun*1, LI Hao-Yang1, LIU Qi-Tao2   

  1. (1 Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142)
    (2 Institute of Chemical Science and Engineering, Liaoning University, Shenyang 110036)
  • Received:2004-08-06 Revised:2005-03-04 Published:2010-12-10
  • Contact: GAO En-Jun

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A single crystal of [Pd(L-tyr)2]•0.5H2O was synthesized, and it belongs to monoclinic system with space group P2(1). Oxygen atom of carboxyl and nitrogen atom of azyl coordinate with Pd(II) ion to form two planar five-membered rings. There were weak interaction between one coordinate chelate ring and another coordinate chelate ring, π-π stacking between phenolic rings and hydrogen bonds between water molecule and ligand. In water solution, cumulative stability constant β2 of title complex is 1017, and it means that there was strong coordinate-covalent bond between ligand and Pd(II) ion. The interaction of the complex with fish sperm DNA has been studied by UV, fluorescence and CD. The results show that the interaction of the complex with DNA took mainly insertion mode and there was strong interaction between complex and DNA.

Key words: palladium(II), tyrosine, structure, stability constant, DNA