The interactions between eleven flavonoids and BSA were investigated by fluorescence spectroscopy. The binding parameters, including binding constants, binding numbers and binding distance, were calculated. By a comparison of the structures of flavonoids with their binding potency, the structural requirements of flavonoids for the binding were obtained. Furthermore, to explore the effect of molecular structure on the binding, a study on quantitative structure and binding-property relationship (QSPR) was performed on SGI workstations.

Key words: flavonoid, fluorescence spectroscopy, interaction, bovine serum albumin, quantitative structure and binding-property relationship