Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (02): 145-152. Previous Articles     Next Articles

Full Papers

布朗动力学理论模拟动态肌动蛋白纤维的增长

郭坤琨*,1,韩文驰2   

  1. (1湖南大学材料科学与工程学院 长沙 410082)
    (2沈阳化工大学材料科学与工程学院 沈阳 110142)
  • 投稿日期:2010-06-18 修回日期:2010-08-24 发布日期:2010-09-17
  • 通讯作者: 郭坤琨 E-mail:kunkunguo@hnu.edu.cn
  • 基金资助:

    细胞骨架的增长以及其在细胞运动中的作用机理

Growth of Dynamic Actin Filament via Brownian Dynamics Simulations

Guo Kunkun*,1 Han Wenchi2   

  1. (1 College of Materials Science and Technology, Hunan University, Changsha 410082)
    (2 College of Materials Science and Technology, Shenyang University of Chemical Technology, Shenyang 110142)
  • Received:2010-06-18 Revised:2010-08-24 Published:2010-09-17
  • Contact: Kun kunkunkun E-mail:kunkunguo@hnu.edu.cn
  • Supported by:

    The growth of cytoskeleton and its mechanism to cell movement

Actin polymerization is coupled with the hydrolysis of adenosine triphosphate (ATP). The hydrolysates of ATP are adenosine diphosphate (ADP) and inorganic phosphate (Pi). Therefore, each protomer within the actin filament can exhibit three different nucleotide states corresponding to bounded ATP, ADP/Pi and ADP molecules. These protomer states cause the filaments to form different spatial patterns, which will change various properties of the filament. The related model has been made to simulate the process of polymerization, depolymerization and hydrolysis via Brownian dynamics simulations, where the time evolution of depolymerization and hydrolysis is described as a continuous-time Markov process. In this paper, we focus on how to realize the chemical equilibrium between two ends of the filament, and study the growth behavior of long filaments as a function of ATP-actin monomer concentration.

Key words: brownian dynamics, actin filament, polymerization, depolymerization