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Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (21): 2561-2566.DOI: 10.6023/A1103214B Previous Articles Next Articles
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史艳萍,陈宝泉*,麻静,刘玉明,李彩文
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国家自然科学基金
SHI Yan-Ping, CHEN Bao-Quan, MA Jing, LIU Yu-Ming, LI Cai-Wen
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Ten novel 2-(2-substituted 1,3,4-thiadiazol-5-yl)benzisoselenazol-3(2H)-one derivatives (6) were synthesized by the condensation of 2-chloroselenobenzoyl chloride and 2-amino-5-substituted 1,3,4-thiadiazole according to substructure link principle, and structurally confirmed by IR, 1H NMR, ESI-MS techniques and elemental analysis. The antiproliferative activities against three tumor cells were tested using CCK-8 method. The results indicated that 6h against A-549, 6a, 6b, 6d, 6e, 6f, 6g, 6h, 6j against MCF-7 and 6a, 6b, 6d, 6e, 6f, 6g against SSMC-7721 showed better activities than positive control Ebselen did, which suggested such compounds with a certain selectivity to the three tumor cells and were worth further investigation.
Key words: selenium, benzisoselenazolone, 1,3,4-thiadiazole, synthesis, antitumor activity
SHI Yan-Ping, CHEN Bao-Quan, MA Jing, LIU Yu-Ming, LI Cai-Wen. Synthesis and Antitumor Activity of 2-(2-Substituted 1,3,4-thiadiazol-5-yl)benzisoselenazol-3(2H)-one Derivatives[J]. Acta Chimica Sinica, 2011, 69(21): 2561-2566.
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