Synthesis of PtBA-g-PPEGMEMA Graft Copolymer and Its Loading of DOX

doi:10.6023/A1111252

Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (01): 92-98.DOI: 10.6023/A1111252 Previous Articles Next Articles

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PtBA-g-PPEGMEMA接枝共聚物的合成及其包埋阿霉素的研究

郑兴良, 丁爱顺, 罗丹, 高鸿盛

长沙理工大学化学与生物工程学院, 长沙 410076

投稿日期:2011-11-25 修回日期:2011-12-19 发布日期:2012-02-25
通讯作者: 郑兴良 E-mail:xingliangzheng@163.com
基金资助:
国家自然科学基金(No.20976017)和中国科学院上海有机化学研究所有机氟化学重点实验室开放基金2011资助项目.

Synthesis of PtBA-g-PPEGMEMA Graft Copolymer and Its Loading of DOX

Zheng Xingliang, Ding Aishun, Luo Dan, Gao Hongsheng

Institute of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha 410076

Received:2011-11-25 Revised:2011-12-19 Published:2012-02-25
Supported by:
Project supported by the National Natural Science Foundation of China(No.20976017)and 2011 Foundation of Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,CAS.

PtBA-g-PPEGMEMA amphiphilic graft copolymer,consisting of poly(tert-butylacrylate)back- bone and poly(poly(ethylene glycol)methyl ether methacrylate)side chains,was synthesized by the combi- nation of reversible addition-fragmentation chain transfer(RAFT)polymerization and atom transfer radical polymerization(ATRP).The limitation of low and uncontrolled grafting density while introducing the grafting points onto the polymer backbone by polymer post-modification can be overcome by this strategy.The anti-cancer drug,doxorubicin (DOX),was loaded using PtBA-g-PPEGMEMA as the carrier to get a DOX-loaded micelle-based nano-carrier with a D_h around 164.8nm.Drug release experiment of the nano-carrier indicated the delayed drug release characteristics.

Key words: amphiphilic graft copolymer, RAFT, ATRP, drug carrier

Cite this article

Zheng Xingliang, Ding Aishun, Luo Dan, Gao Hongsheng. Synthesis of PtBA-g-PPEGMEMA Graft Copolymer and Its Loading of DOX[J]. Acta Chimica Sinica, 2012, 70(01): 92-98.

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PtBA-g-PPEGMEMA接枝共聚物的合成及其包埋阿霉素的研究

Synthesis of PtBA-g-PPEGMEMA Graft Copolymer and Its Loading of DOX

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