Synthesis, Characterization and Biological Activity of Piperidinothienopyrimidinones

doi:10.6023/A1108221

Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (06): 759-764.DOI: 10.6023/A1108221 Previous Articles Next Articles

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哌啶并噻吩并嘧啶酮衍生物的合成、表征及生物活性

曾国平, 郑平

湖北第二师范学院化学与生命科学学院武汉 430205

投稿日期:2011-08-22 修回日期:2011-10-21 发布日期:2011-12-01
通讯作者: 郑平
基金资助:
湖北省教育厅科研项目(No. B20113001), 湖北第二师范学院重点学科“应用化学”(No. 201008)资助项目.

Synthesis, Characterization and Biological Activity of Piperidinothienopyrimidinones

Zeng Guoping, Zheng Ping

School of Chemistry and Life Sciences, Hubei University of Education, Wuhan 430205

Received:2011-08-22 Revised:2011-10-21 Published:2011-12-01
Supported by:
Project supported by the Hubei Province Department of Education Scientific Research (No. B20113001), Hubei University of Education Key Disciplines “Applied Chemistry” (No. 201008).

Nine new piperidinothienopyrimidinone derivatives were synthesized from the reaction of carbodiimide intermediate with primary, secondary amines and alcohols catalyzed by sodium alkoxide. The structures of the compound were confirmed by elemental analysis, ¹H NMR, MS and single crystal X-ray determination. The fungicidal activities of all the compounds were studied and some compounds exhibited good bacteriostasis activity. Among them, compound 7b exhibited fungicidal activity against Botrytis cinereapers, Rhizoctonia solani, and Gibberella zeae with inhibitive rates of 76.19%, 68.83% and 56.52%, respectively.

Key words: piperidinothienopyrimidinone, synthesis, characterization, biological activity

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Zeng Guoping, Zheng Ping. Synthesis, Characterization and Biological Activity of Piperidinothienopyrimidinones[J]. Acta Chimica Sinica, 2012, 70(06): 759-764.

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哌啶并噻吩并嘧啶酮衍生物的合成、表征及生物活性

Synthesis, Characterization and Biological Activity of Piperidinothienopyrimidinones

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