Acta Chimica Sinica ›› 2020, Vol. 78 ›› Issue (3): 232-244.DOI: 10.6023/A20010006 Previous Articles Next Articles
Review
郄淑燕a, 郝莹b, 刘宗建a, 王锦b, 席家宁a
投稿日期:
2020-01-08
发布日期:
2020-02-26
通讯作者:
王锦, 席家宁
E-mail:jwang2014@sinano.ac.cn;xijn888@sina.com
作者简介:
郄淑燕,女,主任医师、副教授,首都医科大学附属北京康复医院康复诊疗中心主任,现任中华医学会物理医学与康复学分会康复治疗学组副组长,中国康复医学会康复机构管理专委会常务委员,中国康复医学会运动疗法专业委员会委员、水中运动疗法学组副主委,北京医师协会康复医学专科医师分会常务理事,石景山区重点学科学术带头人.2018年获"北京优秀医师".目前参与科技部重点课题2项,主持省部级课题1项,获省级科技进步奖2次.主编著作1部,主译著作2部,副主编著作和教材4部,以第一或通信作者发表SCI文章5篇,合作发表SCI文章4篇;郝莹,女,副研究员.2013年毕业于苏州大学,获高分子化学与物理专业博士学位,2014年至2017年在美国University of Delaware材料科学与工程系从事博士后研究,2017年8月加入中国科学院苏州纳米所,任副研究员;主要研究方向包括高分子合成化学、功能生物材料以及干细胞定向分化研究;主持国家自然科学基金青年基金1项,发表SCI论文20余篇,获中国发明专利授权3项;刘宗建,男,副研究员.2013年于北京理工大学生命学院获应用化学博士学位,2015年于首都医科大学宣武医院神经生物学博士后出站.现担任首都医科大学附属北京康复医院科研管理部主任、中国电子学会生命电子分会委员、中国老年医学会脑血管分会青年委员.主要研究方向为免疫调控和炎症反应在脑卒中康复的作用机制研究,主持国家自然科学基金面上项目1项和北京市自然科学基金1项,获教育部科技进步奖1项.以第一/通讯作者发表SCI收录论文12篇,EI收录论文2篇;王锦,男,副研究员,硕士生导师.2012年获北京理工大学材料学博士学位,2012年至2014年分别于日本东京工业大学和山形大学从事博士后研究,2014年回国加入中国科学院苏州纳米所任副研究员.主要研究方向为智能超分子水凝胶/气凝胶设计合成及其在生物、能源、环境中的应用,迄今发表SCI论文40余篇,申请发明专利20余项(已授权8项),主持国家自然科学基金3项、江苏省自然科学基金及苏州市科技局等项目近10项,作为主要研究人员参与国家重点研发计划、中国科学院重点部署专项等数10项科研项目;席家宁,男,教授,主任医师,硕士生导师,首都医科大学附属北京康复医院、北京康复医学院院长,首都医科大学康复学系副主任,康复医学与理疗学专业学科带头人.成功带领传统疗养院转型为学院型康复医院,是现代康复医院建设的引领者,"大康复,强综合"康复医院运营管理模式的开拓者和实践者.创立了"以组织系统为基础,以器官功能为核心"的学科架构理论体系,为中国康复医学事业发展做出了突出贡献,荣获"首都劳动奖章".担任中国康复医疗机构联盟主席、中国康复医学会康复机构管理专委会主任委员等.主持多项省部级及以上课题,担任《中国康复科学杂志》主编、《中华临床医师杂志》常务编审等,出版专业著作6部.
基金资助:
Qie Shuyana, Hao Yingb, Liu Zongjiana, Wang Jinb, Xi Jianinga
Received:
2020-01-08
Published:
2020-02-26
Supported by:
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Qie Shuyan, Hao Ying, Liu Zongjian, Wang Jin, Xi Jianing. Advances in Cyclodextrin Polymers and Their Applications in Biomedicine[J]. Acta Chimica Sinica, 2020, 78(3): 232-244.
[1] Crini, G. Chem. Rev. 2014, 114, 10940. [2] Yu, G.; Jie, K.; Huang, F. Chem. Rev. 2015, 115, 7240. [3] Chen, Y.; Gui, X.; Duan, Z.; Zhu, L.; Xiang, Y.; Xia, D. Chin. J. Org. Chem. 2019, 39, 1284(in Chinese). (陈雅琪, 桂鑫, 段尊斌, 朱丽君, 项玉芝, 夏道宏, 有机化学, 2019, 39, 1284.) [4] Shao, W.; Liu, X.; Wang, T.; Hu, X. Chin. J. Org. Chem. 2018, 38, 1107(in Chinese). (邵为, 刘昕, 王婷婷, 胡晓玉, 有机化学, 2018, 38, 1107.) [5] Liu, A.; Xiong, C.; Ma, X.; Ma, W.; Sun, R. Chin. J. Chem. 2019, 37, 793. [6] Chen, X.; Chen, Y.; Liu, Y. Chin. J. Chem. 2018, 36, 526. [7] Zhang, Y.; Chen, Y.; Li, J.; Liang, L.; Liu, Y. Acta Chim. Sinica 2018, 76, 622. (张依, 陈湧, 李晶晶, 梁璐, 刘育, 化学学报, 2018, 76, 622.) [8] Ren, K.; He, J.; Zhang, M.; Wu, Y.; Ni, P. Acta Chim. Sinica 2015, 73, 1038(in Chinese). (任锴, 何金林, 张明祖, 吴一弦, 倪沛红, 化学学报, 2015, 73, 1038.) [9] Li, Q.; Wang, J.; Ye, L.; Zhang, A.; Zhang, X.; Feng, Z. Chem-NanoMat 2019, 5, 838. [10] Frieler, L.; Ho, T. M.; Anthony, A.; Hidefumi, Y.; Yago, A. J. E.; Bhandari, B. R. J. Food Sci. Technol. 2019, 56, 1519. [11] Ho, T. M.; Bhandari, B. R. Powder Technol. 2015, 17, 585. [12] Morin-Crini, N.; Crini, G. Prog. Polym. Sci. 2013, 38, 344. [13] Morin-Crini, N.; Winterton, P.; Fourmentin, S.; Wilson, L. D.; Fenyvesi, E.; Crini, G. Prog. Polym. Sci. 2018, 78, 1. [14] Manakker, F. V. D.; Vermonden, T.; Nostrum, C. F.; Hennink, W. E. Biomacromolecules 2009, 10, 3157. [15] Solms, J.; Egli, R. H. Helv. Chim. Acta 1965, 48, 1225. [16] Solms, J. US 3420788, 1969. [17] Harada, A.; Li, J.; Kamachi, M. J. Am. Chem. Soc. 1994, 116, 3192. [18] Xu, M.; Zhang, Y. Polym. Mater. Sci. Eng. 2010, 26, 162(in Chinese). (徐美芸, 章永化, 高分子材料科学与工程, 2010, 26, 162.) [19] Arisaka, Y.; Yui, N. J. Mater. Chem. B 2019, 7, 2123. [20] Gao, P.; Wang, P.; Geng, X.; Ye, L.; Zhang, A.; Feng, Z. Acta Chim. Sinica 2013, 71, 347(in Chinese). (高鹏, 王培境, 耿雪, 叶霖, 张爱英, 冯增国, 化学学报, 2013, 71, 347.) [21] Li, H.; Wang, J.; Ni, Y.; Zhou, Y.; Yan, D. Acta Chim. Sinica 2016, 74, 415(in Chinese). (李惠梅, 王洁, 倪云洲, 周永丰, 颜德岳, 化学学报, 2016, 74, 415.) [22] Arunachalam, M.; Harry, W. G. Prog. Polym. Sci. 2014, 39, 1043. [23] Hashidzume, A.; Yamaguchi, H.; Harada, A. Eur. J. Org. Chem. 2019, 21, 3344. [24] Harada, A.; Hashidzume, A.; Yamaguchi, H.; Takashima, Y. Chem. Rev. 2009, 109, 5974. [25] Okada, M.; Kamachi, M.; Harada, A. Macromolecules 1999, 32, 7202. [26] Harada, A.; Kawaguchi, Y.; Nishiyama, T.; Kamachi, M. Macromol. Rapid. Commun. 1997, 18, 535. [27] Rusa, C. C.; Tonelli, A. E. Macromolecules 2000, 33, 5321. [28] Harada, A.; Suzuki, S.; Okada, M.; Kamachi, M. Macromolecules 1996, 29, 5611. [29] Okumura, H.; Kawaguchi, Y.; Harada, A. Macromolecules 2001, 34, 6338. [30] Loethen, S.; Kim, J. M.; Thompson, D. H. Polym. Rev. 2007, 47, 383. [31] Wang, P. J.; Wang, J.; Ye, L.; Zhang, A.; Feng, Z. G. Polymer 2012, 53, 2361. [32] Wang, J.; Li, S.; Ye, L.; Zhang, A.; Feng, Z. G. Macromol. Rapid Commun. 2012, 33, 1143. [33] Kato, K.; Kamotsu, H.; Ito, K. Macromolecules 2010, 43, 8799. [34] Yu, S.; Zhang, Y.; Wang, X.; Zhen, X.; Zhang, Z.; Wu, W.; Jiang, X. Angew. Chem., Int. Ed. 2013, 52, 7272. [35] Zhang, X. W.; Zhu, X. Q.; Tong, X. M.; Ye, L.; Zhang, A.; Feng, Z. G. J. Polym. Sci. Part A:Polym. Chem. 2008, 46, 5283. [36] Ren, L. X.; Ke, F. Y.; Chen, Y. M.; Liang, D.; Huang, J. Macromolecules 2008, 41, 5295. [37] Dai, X. H.; Dong, C. M.; Yan, D. Y. J. Phys. Chem. B 2008, 112, 3644. [38] Wang, J.; Gao, P.; Ye, L.; Zhang, A.; Feng, Z. G. J. Phys. Chem. B 2010, 114, 5342. [39] Wang, J.; Ye, L.; Zhang, A.; Feng, Z. G. J. Mater. Chem. 2011, 21, 3243. [40] Wang, J.; Gao, P.; Wang, P. J.; Ye, L.; Zhang, A.; Feng, Z. G. Polymer 2011, 52, 374. [41] Wang, J.; Gao, P.; Ye, L.; Zhang, A.; Feng, Z. G. Polym. Chem. 2011, 2, 931. [42] Wang, J.; Wang, P. J.; Ye, L.; Zhang, A.; Feng, Z. G. Polymer 2011, 52, 5362. [43] Wang, J.; Gao, P.; Jiang, L.; Ye, L.; Zhang, A.; Feng, Z. G. Polymer 2012, 53, 2864. [44] Duan, N.; Lu, H.; Ye, L.; Zhang, A.; Feng, Z. G. J. Phys. Chem. B 2019, 123, 5004. [45] Kong, T.; Ye, L.; Zhang, A.; Feng, Z. G.; Langmuir 2018, 34, 14076. [46] Gao, M.; Lu, H.; Song, R. H.; Ye, L.; Zhang, A.; Feng, Z. G. Polym. Chem. 2020, 11, 653. [47] Wang, J.; Zhang, X. ACS Nano 2015, 9, 11389. [48] Wang, J.; Du, R.; Zhang, X. ACS Appl. Mater. Interfaces 2018, 10, 1468. [49] Uenuma, S.; Maeda, R.; Yokayama, H.; Ito, K. Chem. Commun. 2019, 55, 4158. [50] Uenuma, S.; Maeda, R.; Yokoyama, H.; Ito, K. Macromolecules 2019, 52, 3881. [51] Arisaka, Y.; Yui, N. Macromol. Rapid Commun. 2019, 40, 1900323. [52] Demirci, S.; Kinali-Demirci, S.; Jiang, S. Chem. Commun. 2017, 53, 3713. [53] Zhang, L.; Zhao, J.; Wang, Y. Acta Chim. Sinica 2015, 73, 1182(in Chinese). (张丽芳, 赵杰, 王勇, 化学学报, 2015, 73, 1182.) [54] Lucio, D.; Martinez-Oharriz, M. C.; Gu, Z.; He, Y.; Aranaz, P.; Vizmanos, J. L.; Irache, J. M. Int. J. Pharm. 2018, 547, 97. [55] Azmeera, V.; Tungala, K.; Adhikary, P.; Kumar, K.; Krishnamoorthi, S. Int. J. Biol. Macromol. 2017, 104, 1204. [56] Li, L.; Guo, X.; Wang, J.; Liu, P.; Prud'homme, R. K.; May, B. L.; Lincoln, S. F. Macromolecules 2008, 41, 8677. [57] Wang, J.; Guo, Z.; Xiong, J.; Wu, D.; Li, S.; Tao, Y.; Qin, Y.; Kong, Y. Int. J. Biol. Macromol. 2019, 125, 941. [58] Shen, Y.; Niu, L.; Yu, Z.; Wang, M.; Shang, Z.; Yang, Y. Appl. Surf. Sci. 2018, 444, 42. [59] Pooresmaeil, M.; Namazi, H. Colloids Surf. B:Biointer. 2018, 172, 17. [60] Zhang, B.; Yu, Q.; Zhang, Y. M.; Liu, Y. Chem. Commun. 2019, 55, 12200. [61] Bai, L.; Yan, H.; Bai, T.; Feng, Y.; Zhao, Y.; Ji, Y.; Feng, W.; Lu, T.; Nie, Y. Biomacromolecules 2019, 20, 4230. [62] Baimani, N.; Azar, P. A.; Husain, S. W.; Panahi, H. A.; Mehramizi, A. J. Chromatogr. A 2018, 1571, 38. [63] Helal, A. S.; Mazario, E.; Mayoral, A.; Decorse, P.; Losno, R.; Lion, C.; Ammar, S.; Hemadi, M. Environ. Sci. Nano 2018, 5, 158. [64] Hong, S.; Li, Z.; Li, C.; Dong, C.; Shuang, S. Appl. Surface Sci. 2018, 427, 1189. [65] Alsbaiee, A.; Smith, B. J.; Xiao, L.; Ling, Y.; Helbling, D. E.; Dichtel, W. R. Nature 2016, 529, 190. [66] Xu, G.; Xie, X.; Qin, L.; Hu, X.; Zhang, D.; Xu, J.; Li, D.; Ji, X.; Huang, Y.; Tu, Y.; Jiang, L.; Wei, D. Green Chem. 2019, 21, 6062. [67] Wang, J.; Wang, X.; Zhang, X. J. Mater. Chem. A 2017, 5, 4308. [68] Lenohardt, E. E.; Meador, M. A. B.; Wooley, K. L. Chem. Mater. 2018, 30, 6226. [69] Mizuno, S.; Asoh, T. A.; Takashima, Y.; Harada, A.; Uyama, H. Polym. Degrad. Stability 2019, 160, 136. [70] Kretschmann, O.; Choi, S. W.; Miyauchi, M.; Tomatsu, I.; Harada, A.; Ritter, H. Angew. Chem. Int. Ed. 2006, 45, 4361. [71] Cheng, H.; Fan, X.; Wu, C.; Wang, X.; Wang, L. J.; Loh, X. J.; Li, Z.; Wu, Y. L. Macromol. Rapid Commun. 2019, 40, 1800207. [72] Shukula, A.; Singh, A. P.; Ray, B.; Aswal, V.; Kar, A. G.; Maiti, P. J. Colloid Interface Sci. 2019, 534, 215. [73] Cocq, A.; Rousseau, C.; Bricout, H.; Oliva, E.; Bonnet, V.; Djedaini-Pilard, F.; Monflier, E.; Tilloy, S. Eur. J. Org. Chem. 2019, 4863. [74] Furlan, A. L.; Buchoux, S.; Miao, Y.; Banchet, V.; Leteve, M.; Lambertyn, V.; Michel, J.; Sarazin, C.; Bonnet, V. New J. Chem. 2018, 42, 20171. [75] Arslan, M.; Sanyal, R.; Sanyal, A. Polym. Chem. 2020, 11, 615. [76] Seo, J. H.; Kakinoki, S.; Inoue, Y.; Yamaoka, T.; Ishihara, K.; Yui, N. J. Am. Chem. Soc. 2013, 135, 5513. [77] Zhang, Y.; Zhou, Q.; Jia, S.; Lin, K.; Fan, G.; Yuan, J.; Yu, S.; Shi, J. ACS Appl. Mater. Interfaces 2019, 11, 46427. [78] Rajendran, A. K.; Arisaka, Y.; Iseki, S.; Yui, N. ACS Biomater. Sci. Eng. 2019, 5, 5652. [79] Srinivasachari, S.; Fichter, K. M.; Reineke, T. M. J. Am. Chem. Soc. 2008, 130, 4618. [80] Li, J.; Yang, C.; Li, H.; Wang, X.; Goh, S. H.; Ding, J. L.; Wang, D. Y.; Leong, K. W. Adv. Mater. 2006, 18, 2969. [81] Zhang, J.; Zhang, L.; Li, S.; Yin, C.; Li, C.; Wu, W.; Jiang, X. ACS Biomater. Sci. Eng. 2018, 4, 1963. [82] Zhang, Y.; Zhang, Z.; Chen, W.; Li, C.; Wu, W.; Jiang, X. Acta Polym. Sinica 2017, 48, 306(in Chinese). (张亚军, 张正奎, 陈伟芝, 李成, 武伟, 蒋锡群, 高分子学报, 2017, 48, 306.) [83] Kim, H.; Han, J.; Park, J. H. J. Control. Release 2020, 319, 77. [84] Li, X.; Liu, H.; Li, J.; Deng, Z.; Li, L.; Liu, J.; Yuan, J.; Gao, P.; Yang, Y.; Zhong, S. Colloids Surf. B:Biointer. 2019, 183, 110425. [85] Huang, T.; Sheng, G.; Manchanda, P.; Emwas, A. H.; Lai, Z.; Nunes, S. P.; Peinemann, K. V. Sci. Adv. 2019, 5, eaax6976. [86] Pierre, A. C.; Pajonk, G. M. Chem. Rev. 2002, 102, 4243. [87] Wang, J.; Wei, Y.; He, W.; Zhang, X. RSC Adv. 2014, 4, 51146. [88] Wang, J.; Zhang, Y.; Wei, Y.; Zhang, X. Micropor. Mesopor. Mater. 2015, 218, 192. [89] Wang, J.; Zhang, Y.; Zhang, X. J. Mater. Chem. A 2016, 4, 11408. [90] Li, X.; Wang, J.; Zhao, Y.; Zhang, X. ACS Appl. Mater. Interfaces 2018, 10, 16901. [91] Liu, R.; Wang, J.; Du, Y.; Liao, J.; Zhang, X. J. Solid State Chem. 2019, 279, 120971. [92] Jiang, L.; Kato, K.; Mayumi, K.; Yokoyama, H.; Ito, K. ACS Macro Lett. 2017, 6, 281. [93] Matias, T.; Marques, J.; Conceicao, F.; Maleki, H.; Quina, M. J.; Gando-Ferreira, L.; Valente, A. J. M.; Portugal, A.; Duraes, L. J. Sol-Gel Sci. Technol. 2017, 84, 409. [94] Zhou, K.; Li, Y.; Li, Q.; Du, Q.; Wang, D.; Sui, K.; Wang, C.; Li, H.; Xia, Y. J. Polym. Environ. 2018, 26, 3362. [95] Jia, H.; Tian, Q.; Xu, J.; Lu, L.; Ma, X.; Yu, Y. Microchim. Acta 2018, 185, 517. [96] Xie, Y.; Tu, X.; Ma, X.; Fang, Q.; Lu, L.; Yu, Y.; Liu, G.; Liu, C. Nanotechnology 2019, 30, 185502. [97] Noda, Y.; Hayashi, Y.; Ito, K. J. Appl. Polym. Sci. 2014, 131, 40509. [98] Li, S.; Wang, J.; Gao, P.; Ye, L.; Zhang, A.; Feng, Z. G. Sci. China Chem. 2012, 55, 1115. [99] Li, S.; Wang, J.; Jiang, L.; Ye, L.; Zhang, A.; Feng, Z. G. Chin. J. Chem. 2012, 30, 2453. [100] Okumura, Y.; Ito, K. Adv. Mater. 2001, 13, 48. [101] Araki, J.; Ito, K. Soft Matter 2007, 3, 1456. [102] Voorhaar, L.; Hoogenboom, R. Chem. Soc. Rev. 2016, 45, 4013. [103] Tan, M.; Wang, J.; Song, W.; Fang, J.; Zhang, X. J. Mater. Chem. A 2019, 7, 1244. [104] Buwalda, S. J.; Boere, K. W. M.; Dijkstra, P. J.; Feijen, J.; Ver-monden, T.; Hennink, W. E. J. Control. Release 2014, 190, 254. [105] Shinohaea, Y.; Kayashima, K.; Okumura, Y.; Zhao, C.; Ito, K.; Amemiya, Y. Macromolecules 2006, 39, 7386. |
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