Study on the Interaction of β-1,2,3,4,6-Penta- O-galloyl- D-glucopyranose with Human Serum Albumin

Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (16): 1460-1466. Previous Articles Next Articles

β-1,2,3,4,6-五-O-倍酰-D-葡萄糖与人血清白蛋白的相互作用研究

谢孟峡, 蒋敏, 李崧, 刘媛

北京师范大学分析测试中心, 北京, 100875

投稿日期:2004-02-03 修回日期:2004-04-20 发布日期:2014-02-17
通讯作者: mengxia-xie@263.net
作者简介:谢孟峡,E-mail:mengxia-xie@263.net

Study on the Interaction of β-1,2,3,4,6-Penta- O-galloyl- D-glucopyranose with Human Serum Albumin

XIE Meng-Xia, JIANG Min, LI Song, LIU Yuan

Analytical & Testing Center of Beijing Normal University, Beijing 100875

Received:2004-02-03 Revised:2004-04-20 Published:2014-02-17

Abstract

Interaction of β-1,2,3,4,6-penta-O-galloyl-D-glucopyranose (PGG) with human serum albumin (HSA) has been studied by Fourier transform infrared (FT-IR) and fluorescence spectroscopic methods.Fluorescence data revealed the presence of one binding site on HSA when C_PGG/C_HSA<0.5, and two sites when 0.5<C_PGG/C_HSA<3.The binding constants (K_A) are 1 66吆 4 and 8 98吆 8 L·mol -1 in the two concentration ranges respectively.The changes of the secondary structure of HSA after interacting with PGG were estimated by combining the curve-fitting results of amide Ⅰ and amide Ⅲ bands of the protein infrared spectra.It was found that with the increase of PGG concentration, the interaction of PGG with HSA has mainly caused the change from the α-helix structure to β-turn and random coil structure.Combining the results of fluorescence and FT-IR, the relationship of fluorescence quenching and the changes of HSA secondary structure induced by PGG binding was investigated, and the PGG-HSA interaction mode was discussed.

Key words: β-1,2,3,4,6-penta-O-galloyl-D-glucopyranose, human serum albumin, FT-IR, fluorescence, secondary structure

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XIE Meng-Xia, JIANG Min, LI Song, LIU Yuan. Study on the Interaction of β-1,2,3,4,6-Penta- O-galloyl- D-glucopyranose with Human Serum Albumin[J]. Acta Chimica Sinica, 2004, 62(16): 1460-1466.

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β-1,2,3,4,6-五-O-倍酰-D-葡萄糖与人血清白蛋白的相互作用研究

Study on the Interaction of β-1,2,3,4,6-Penta- O-galloyl- D-glucopyranose with Human Serum Albumin

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