Fluorescence Imaging of Active Molecules Associated with Depression★

doi:10.6023/A23040191

Acta Chimica Sinica ›› 2023, Vol. 81 ›› Issue (9): 1255-1264.DOI: 10.6023/A23040191 Previous Articles

Special Issue: 庆祝《化学学报》创刊90周年合辑

Review

抑郁症相关活性分子的荧光成像^★

车飞达, 赵晓茗, 张馨, 丁琪, 王昕^*(), 李平^*(), 唐波^*()

山东师范大学化学化工材料与科学学院济南 250014

投稿日期:2023-04-30 发布日期:2023-06-27

作者简介:

车飞达, 山东师范大学化学化工与材料科学学院在读博士研究生. 研究方向为抑郁症相关分子的细胞与活体荧光成像.

赵晓茗, 山东师范大学化学化工与材料科学学院在读硕士研究生. 研究方向为抑郁症相关分子的细胞与活体荧光成像.

张馨, 在山东师范大学化学化工与材料科学学院在读硕士生. 研究方向为抑郁症相关分子的细胞与活体荧光成像.

丁琪, 山东师范大学化学化工与材料科学学院在读博士研究生. 研究方向为抑郁症相关分子的细胞与活体荧光成像.

王昕, 2020年毕业于山东师范大学, 获博士学位. 主要从事抑郁症相关活性分子的细胞与活体荧光成像工作.

李平, 2008年毕业于山东师范大学, 获博士学位. 1998年加入山东师范大学, 现任化学化工与材料科学学院教授, 国家百千万人才工程入选者、泰山特聘教授、长江学者创新研究带头人. 主要从事新型荧光探针的构建及细胞与活体荧光成像研究工作.

唐波, 1994年获南开大学博士学位. 同年进入山东师范大学化学化工与材料科学学院担任教授, 为国家杰出青年科学家基金获得者, “973计划”首席科学家. 主要从事分析化学及细胞与活体荧光成像研究工作.

^★庆祝《化学学报》创刊90周年.

基金资助:
国家自然科学基金(22134004); 国家自然科学基金(21927811); 国家自然科学基金(22074083); 及山东省自然科学基金(ZR2020ZD17)

Fluorescence Imaging of Active Molecules Associated with Depression^★

Feida Che, Xiaoming Zhao, Xin Zhang, Qi Ding, Xin Wang(), Ping Li(), Bo Tang()

Shandong Normal University, College of Chemical Materials and Science, Jinan 250014

Received:2023-04-30 Published:2023-06-27
Contact: *E-mail: xinwang@sdnu.edu.cn; lip@sdnu.edu.cn; tangb@sdnu.edu.cn
About author:
^★Dedicated to the 90th anniversary of Acta Chimica Sinica.
Supported by:
The National Natural Science Foundation of China(22134004); The National Natural Science Foundation of China(21927811); The National Natural Science Foundation of China(22074083); The Natural Science Foundation of Shandong Province of China(ZR2020ZD17)

Depression is a typical condition of depressive disorder, which takes great burden to family and society. However, the current uncertainty about the etiology and pathogenesis has greatly hindered the development of effective antidepressant drugs. Changes in the levels of active molecules associated with depression, such as reactive oxygen species, neurotransmitters and proteins, play a key role in the occurrence and development of depression. Therefore, detection of active molecules related to depression is particularly important for understanding the pathogenesis of depression. Fluorescence imaging has the advantages of high sensitivity, intuition, in situ, real-time, etc. Therefore, fluorescence imaging technology has become an effective method to monitor the active molecules related to depression. Researchers have effectively detected these active molecules using fluorescence imaging. The recent progress in fluorescence imaging detection of reactive oxygen species (ROS), monoamine neurotransmitters and monoamine oxidase in the active molecules associated with depression in the past five years are reviewed with focus on the development of fluorescence probes and prospects.

Key words: depression, fluorescence imaging, reactive oxygen species (ROS), neurotransmitter, enzyme

Cite this article

Feida Che, Xiaoming Zhao, Xin Zhang, Qi Ding, Xin Wang, Ping Li, Bo Tang. Fluorescence Imaging of Active Molecules Associated with Depression^★[J]. Acta Chimica Sinica, 2023, 81(9): 1255-1264.

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Fig. & Tab. 11

Figure 1. Chemical structure of ROS related fluorescent probes

Figure 3. Representative images (left), fluorescence response traces (middle) and group data (right) of the fluorescence response in cultured rat cortical neurons expressing 5-HT1.0 (green) or 5-HTmut (gray)[41] (Copyright 2023 Springer Nature)

Figure 5. Top, schematic of dual-color photometry in the NAc of wild-type rats coexpressing RdLight1 injected in the NAc and axon- GCaMP6f injected in mPFC. Bottom, representative micrograph showing RdLight1 in red and axon-GCaMP6f in green[50] (Copyright 2023 Springer Nature)

Figure 6. Chemical structure of neurotransmitter related fluorescent probes

Figure 7. (a~c) In vivo imaging of rats intraperitoneally injected with saline and (d~f) in vivo imaging of rats intraperitoneally injected with fluoxetine[52] (Copyright 2020 American Chemical Society)

Figure 8. Chemical structure of MAO related fluorescent probes

Figure 10. Fluorescence images of 80 μmol/L $O_{2}^{.-}$ stimulated neurons in the presence of 17[66] (Copyright The Royal Society of Chemistry 2022)

References 69

[1]	Steven, M.; Edward, P.; Trisha, S.; Emily, C.; Allan, Y.; Rachel, U. The Lancet 2023, 401, 141. doi: 10.1016/S0140-6736(22)02080-3
[2]	Clark, D. C.; Cavanaugh, S. V.; Gibbons, R. D. J. Nerv. Ment. Dis. 1983, 171, 705. pmid: 6644280
[3]	Miller, A. H.; Haroon, E.; Raison, C. L.; Felger, J. C. Depression Anxiety 2013, 30, 297. doi: 10.1002/da.2013.30.issue-4
[4]	Franklin, T. C.; Xu, C.; Duman, R. S. Brain, Behav., Immun. 2018, 72, 2.
[5]	Bhatt, S.; Nagappa, A. N.; Patil, C. R. Drug Discovery Today 2020, 25, 1270. doi: 10.1016/j.drudis.2020.05.001
[6]	Maes, M.; Galecki, P.; Chang, Y. S.; Berk, M. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2011, 35, 676. doi: 10.1016/j.pnpbp.2010.05.004
[7]	Bilici, M.; Efe, H.; Köroğlu, M. A.; Uydu, H. A.; Bekaroğlu, M.; Değer, O. J. Affective Disord. 2001, 64, 43. doi: 10.1016/S0165-0327(00)00199-3
[8]	Schildkraut, J. J.; Kety, S. S. Science 1967, 156, 21. pmid: 5335690
[9]	Coppen, A.; Wood, K. M. Acta Psychiatr. Scand. 1980, 61, 21.
[10]	Randrup, A.; Bræstrup, C. Psychopharmacology 1977, 53, 309. pmid: 408861
[11]	Janowsky, D.; Davis, J.; El-Yousef, M. K.; Sekerke, H. J. The Lancet 1972, 300, 632. doi: 10.1016/S0140-6736(72)93021-8
[12]	Heien, M. L. A. V.; Johnson, M. A.; Wightman, R. M. Anal. Chem. 2004, 76, 5697. doi: 10.1021/ac0491509
[13]	Estevão, M. S.; Carvalho, L. C.; Ferreira, L. M.; Fernandes, E.; Marques, M. M. B. Tetrahedron Lett. 2011, 52, 101. doi: 10.1016/j.tetlet.2010.10.172
[14]	Ross, A. R. S.; Ambrose, S. J.; Cutler, A. J.; Allan Feurtado, J.; Kermode, A. R.; Nelson, K.; Zhou, R.; Abrams, S. R. Anal. Biochem. 2004, 329, 324. doi: 10.1016/j.ab.2004.02.026
[15]	Duicu, O. M.; Lighezan, R.; Sturza, A.; Balica, R.; Vaduva, A.; Feier, H.; Gaspar, M.; Ionac, A.; Noveanu, L.; Borza, C.; Muntean, D. M.; Mornos, C. Oxid. Med. Cell. Longevity 2016, 8470394.
[16]	Meissner, G. W.; Nern, A.; Singer, R. H.; Wong, A. M.; Malkesman, O.; Long, X. Genetics 2018, 211, 473. doi: 10.1534/genetics.118.301749
[17]	Ye, S.; Zhang, H.; Fei, J.; Wolstenholme, C. H.; Zhang, X. Angew. Chem., Int. Ed. 2021, 60, 1339. doi: 10.1002/anie.v60.3
[18]	Liu, J.; Zhang, W.; Zhou, C.; Li, M.; Wang, X.; Zhang, W.; Liu, Z.; Wu, L.; James, T. D.; Li, P.; Tang, B. J. Am. Chem. Soc. 2022, 144, 13586. doi: 10.1021/jacs.2c03832
[19]	Zhao, Y.; Kim, H. S.; Zou, X.; Huang, L.; Liang, X.; Li, Z.; Kim, J. S.; Lin, W. J. Am. Chem. Soc. 2022, 144, 20854. doi: 10.1021/jacs.2c08966
[20]	Ren, J.-B.; Wang, L.; Guo, R.; Tang, Y.-H.; Zhou, H.-M.; Lin, W.-Y. Acta Chim. Sinica 2021, 79, 87. (in Chinese) doi: 10.6023/A20080399
	(任江波, 王蕾, 郭锐, 唐永和, 周红梅, 林伟英, 化学学报, 2021, 79, 87.) doi: 10.6023/A20080399
[21]	Jiang, G.; Lou, X. F.; Zuo, S.; Liu, X.; Ren, T. B.; Wang, L.; Zhang, X. B.; Yuan, L. Angew Chem., Int. Ed. 2023, 62, e202218613. doi: 10.1002/anie.v62.17
[22]	Li, W.; Yin, S.; Shen, Y.; Li, H.; Yuan, L.; Zhang, X. B. J. Am. Chem. Soc. 2023, 145, 3736. doi: 10.1021/jacs.2c13222
[23]	Wang, X.; Wang, A.-Q.; Qian, M.-R.; Li, B.-X; Jin, L.; Li, T.-H. Chin. J. Anal. Chem. 2023, 4, 531. (in Chinese)
	(王雪, 王安琪, 钱美汝, 李滨汐, 金龙, 李胎花, 分析化学, 2023, 4, 531.)
[24]	Wang, S.-Q.; Luo, B.-W.; Yu, J.-C.; Gu, Z. Chem. J. Chin. Univ. 2022, 43, 20220577. (in Chinese)
	(汪诗琪, 罗博文, 俞计成, 顾臻, 高等学校化学学报, 2022, 43, 20220577.) doi: 10.7503/cjcu20220577
[25]	Liu, B.-D.; Wang, C.-J.; Qian, Y. Acta Chim. Sinica 2022, 80, 1071. (in Chinese) doi: 10.6023/A22040141
	(刘巴蒂, 王承俊, 钱鹰, 化学学报, 2022, 80, 1071.) doi: 10.6023/A22040141
[26]	Xu, N.; Qiao, Q.-L.; Liu, X.-G.; Xu, Z.-C. Acta Chim. Sinica 2022, 80, 553. (in Chinese) doi: 10.6023/A21120578
	(许宁, 乔庆龙, 刘晓刚, 徐兆超, 化学学报, 2022, 80, 553.) doi: 10.6023/A21120578
[27]	Zuo, L.; Zhou, T.; Pannell, B. K.; Ziegler, A. C.; Best, T. M. Acta Physiol. 2015, 214, 329. doi: 10.1111/apha.2015.214.issue-3
[28]	Zhang, W.; Wang, R.; Liu, W.; Wang, X.; Li, P.; Zhang, W.; Wang, H.; Tang, B. Chem. Sci. 2018, 9, 721. doi: 10.1039/c7sc03878j pmid: 29629141
[29]	Schrader, M.; Fahimi, H. D. Biochim. Biophys. Acta, Mol. Cell Res. 2006, 1763, 1755.
[30]	Ding, Q.; Tian, Y.; Wang, X.; Li, P.; Su, D.; Wu, C.; Zhang, W.; Tang, B. J. Am. Chem. Soc. 2020, 142, 20735. doi: 10.1021/jacs.0c09576 pmid: 33237755
[31]	Frangioni, J. V. Curr. Opin. Chem. Biol. 2003, 7, 626. doi: 10.1016/j.cbpa.2003.08.007 pmid: 14580568
[32]	Li, P.; Wang, J.; Wang, X.; Ding, Q.; Bai, X.; Zhang, Y.; Su, D.; Zhang, W.; Zhang, W.; Tang, B. Chem. Sci. 2019, 10, 2805. doi: 10.1039/C8SC04891F
[33]	Chang, C. C.; Lee, C. T.; Lan, T. H.; Ju, P. C.; Hsieh, Y. H.; Lai, T. J. Psychiatry Res. 2015, 230, 575. doi: 10.1016/j.psychres.2015.10.006
[34]	Wang, X.; Li, P.; Ding, Q.; Wu, C.; Zhang, W.; Tang, B. Angew. Chem., Int. Ed. 2019, 58, 4674. doi: 10.1002/anie.v58.14
[35]	Bienert, G. P.; Schjoerring, J. K.; Jahn, T. P. Biochim. Biophys. Acta 2006, 1758, 994. doi: 10.1016/j.bbamem.2006.02.015 pmid: 16566894
[36]	Wang, X.; Ding, Q.; Tian, Y.; Wu, W.; Che, F.; Li, P.; Zhang, W.; Zhang, W.; Tang, B. Chem. Commun. 2022, 58, 6320. doi: 10.1039/D2CC00431C
[37]	Park, H. S.; Kim, S. R.; Lee, Y. C. Respirology 2009, 14, 27. doi: 10.1111/j.1440-1843.2008.01447.x pmid: 19144046
[38]	Zhu, H.; Jia, P.; Wang, X.; Tian, Y.; Liu, C.; Li, X.; Wang, K.; Li, P.; Zhu, B.; Tang, B. Anal. Chem. 2022, 94, 11783. doi: 10.1021/acs.analchem.2c01884
[39]	Mohammad, L. F.; Moses, L.; Gwaltney, S. M. J. Vet. Pharmacol. Ther. 2008, 31, 187. doi: 10.1111/j.1365-2885.2008.00944.x pmid: 18471139
[40]	Unger, E. K.; Keller, J. P.; Altermatt, M.; Liang, R.; Matsui, A.; Dong, C.; Hon, O. J.; Yao, Z.; Sun, J.; Banala, S.; Flanigan, M. E.; Jaffe, D. A.; Hartanto, S.; Carlen, J.; Mizuno, G. O.; Borden, P. M.; Shivange, A. V.; Cameron, L. P.; Sinning, S.; Underhill, S. M.; Olson, D. E.; Amara, S. G.; Temple, L. D.; Rudnick, G.; Marvin, J. S.; Lavis, L. D.; Lester, H. A.; Alvarez, V. A.; Fisher, A. J.; Prescher, J. A.; Kash, T. L.; Yarov-Yarovoy, V.; Gradinaru, V.; Looger, L. L.; Tian, L. Cell 2020, 183, 1986. doi: 10.1016/j.cell.2020.11.040
[41]	Wan, J.; Peng, W.; Li, X.; Qian, T.; Song, K.; Zeng, J.; Deng, F.; Hao, S.; Feng, J.; Zhang, P.; Zhang, Y.; Zou, J.; Pan, S.; Shin, M.; Venton, B. J.; Zhu, J. J.; Jing, M.; Xu, M.; Li, Y. Nat. Neurosci. 2021, 24, 746. doi: 10.1038/s41593-021-00823-7
[42]	Dinarvand, M.; Neubert, E.; Meyer, D.; Selvaggio, G.; Mann, F. A.; Erpenbeck, L.; Kruss, S. Nano Lett. 2019, 19, 6604. doi: 10.1021/acs.nanolett.9b02865 pmid: 31418577
[43]	Berke, J. D. Nat. Neurosci. 2018, 21, 787. doi: 10.1038/s41593-018-0152-y
[44]	Liu, Y.; Li, W.; Wu, P.; Ma, C.; Wu, X.; Xu, M.; Luo, S.; Xu, Z.; Liu, S. Sens. Actuators, B 2019, 281, 34.
[45]	Alizadeh, N.; Salimi, A. Anal. Chim. Acta 2019, 1091, 40. doi: S0003-2670(19)30977-8 pmid: 31679573
[46]	An, J.; Chen, M.; Hu, N.; Hu, Y.; Chen, R.; Lyu, Y.; Guo, W.; Li, L.; Liu, Y. Spectrochim. Acta, Part A 2020, 243, 118804.
[47]	Lin, H.; Huang, J.; Ding, L. J. Nanomater. 2019, 1.
[48]	Naik, V.; Zantye, P.; Gunjal, D.; Gore, A.; Anbhule, P.; Kowshik, M.; Bhosale, S. V.; Kolekar, G. ACS Appl. Bio Mater. 2019, 2, 2069. doi: 10.1021/acsabm.9b00101
[49]	Sangubotla, R.; Kim, J. Mater. Sci. Eng., C 2021, 122, 111916.
[50]	Patriarchi, T.; Mohebi, A.; Sun, J.; Marley, A.; Liang, R.; Dong, C.; Puhger, K.; Mizuno, G. O.; Davis, C. M.; Wiltgen, B.; von Zastrow, M.; Berke, J. D.; Tian, L. Nat. Methods 2020, 17, 1147. doi: 10.1038/s41592-020-0936-3
[51]	Sun, F.; Zhou, J.; Dai, B.; Qian, T.; Zeng, J.; Li, X.; Zhuo, Y.; Zhang, Y.; Wang, Y.; Qian, C.; Tan, K.; Feng, J.; Dong, H.; Lin, D.; Cui, G.; Li, Y. Nat. Methods 2020, 17, 1156. doi: 10.1038/s41592-020-00981-9
[52]	Zhou, N.; Huo, F.; Yue, Y.; Yin, C. J. Am. Chem. Soc. 2020, 142, 17751. doi: 10.1021/jacs.0c08956
[53]	Zhou, N.; Yin, C.; Yue, Y.; Huo, F. Sens. Actuators, B 2022, 373.
[54]	Zhou, N.; Yin, C.; Yue, Y.; Zhang, Y.; Cheng, F.; Huo, F. Chem. Commun. 2022, 58, 2999. doi: 10.1039/D2CC00268J
[55]	Zuo, Z.; Kang, T.; Hu, S.; Su, W.; Gan, Y.; Miao, Z.; Zhao, H.; Feng, P.; Ke, B.; Li, M. Anal. Chem. 2022, 94, 6441. doi: 10.1021/acs.analchem.2c00460
[56]	Zhang, L.; Liu, X. A.; Gillis, K. D.; Glass, T. E. Angew. Chem., Int. Ed. 2019, 58, 7611. doi: 10.1002/anie.v58.23
[57]	Yan, H.; Wang, Y.; Huo, F.; Yin, C. J. Am. Chem. Soc. 2023, 145, 3229. doi: 10.1021/jacs.2c13223
[58]	Feng, J.; Zhang, C.; Lischinsky, J. E.; Jing, M.; Zhou, J.; Wang, H.; Zhang, Y.; Dong, A.; Wu, Z.; Wu, H.; Chen, W.; Zhang, P.; Zou, J.; Hires, S. A.; Zhu, J. J.; Cui, G.; Lin, D.; Du, J.; Li, Y. Neuron 2019, 102, 745. doi: 10.1016/j.neuron.2019.02.037
[59]	Qiao, J.; Wu, D.; Song, Y.; Ji, W.; Yue, Q.; Mao, L.; Qi, L. Anal. Chem. 2021, 93, 14743. doi: 10.1021/acs.analchem.1c03263
[60]	Youdim, M. B. H.; Edmondson, D.; Tipton, K. F. Nat. Rev. Neurosci. 2006, 7, 295.
[61]	Shulman, K. I.; Herrmann, N.; Walker, S. E. CNS Drugs 2013, 27, 789. doi: 10.1007/s40263-013-0097-3
[62]	Zhang, S.; Zhao, B.; Yu, L.; Liu, J.; Zhang, X. Talanta 2020, 209, 120559. doi: 10.1016/j.talanta.2019.120559
[63]	Duangkamol, C.; Wangngae, S.; Wet-Osot, S.; Khaikate, O.; Chansaenpak, K.; Lai, R. Y.; Kamkaew, A. Molecules 2023, 28.
[64]	Dong, J.; Zhang, C.; Zhao, B.; Zhang, X.; Leng, Z.; Liu, J. Dyes Pigm. 2020, 174.
[65]	Meng, Z.; Yang, L.; Yao, C.; Li, H.; Fu, Y.; Wang, K.; Qu, Z.; Wang, Z. Dyes Pigm. 2020, 176.
[66]	Mei, Y.; Liu, Z.; Liu, M.; Gong, J.; He, X.; Zhang, Q. W.; Tian, Y. Chem. Commun. 2022, 58, 6657. doi: 10.1039/D2CC01909D
[67]	Walczak-Nowicka, Ł. J.; Herbet, M. Int. J. Mol. Sci. 2021, 22, 9290. doi: 10.3390/ijms22179290
[68]	Wang, X.; Li, P.; Ding, Q.; Wu, C. C.; Zhang, W.; Tang, B. J. Am. Chem. Soc. 2019, 141, 2061. doi: 10.1021/jacs.8b11414 pmid: 30638380
[69]	Fortibui, M. M.; Jang, M.; Lee, S.; Ryoo, I. J.; Ahn, J. S.; Ko, S. K.; Kim, J. ACS Appl. Bio Mater. 2022, 5, 2232. doi: 10.1021/acsabm.2c00084

抑郁症相关活性分子的荧光成像^★

Fluorescence Imaging of Active Molecules Associated with Depression^★

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抑郁症相关活性分子的荧光成像★

Fluorescence Imaging of Active Molecules Associated with Depression★

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抑郁症相关活性分子的荧光成像^★

Fluorescence Imaging of Active Molecules Associated with Depression^★