Acta Chimica Sinica ›› 2023, Vol. 81 ›› Issue (8): 949-954.DOI: 10.6023/A23040189 Previous Articles     Next Articles

Special Issue: 庆祝《化学学报》创刊90周年合辑

Account

尖晶石氧化物在肿瘤诊疗应用领域研究进展

张媛a, 郑贝宁b, 符美春a, 冯守华a,*()   

  1. a 吉林大学 化学学院无机合成与制备化学国家重点实验室 长春 130012
    b 吉林大学 物理学院 长春 130012
  • 投稿日期:2023-04-30 发布日期:2023-09-14
  • 作者简介:

    张媛, 吉林大学化学学院无机合成与制备化学国家重点实验室工程师. 主要从事无机固体化学的生物医用、水热合成化学与原子级pn结材料的研究.

    郑贝宁, 吉林大学物理学院工程师. 主要研究领域为固体功能材料的合成、分子束外延薄膜的生长及器件研究.

    符美春, 吉林大学化学学院无机合成与制备化学国家重点实验室在读研究生. 主要从事尖晶石氧化物的合成、无机固体化学的生物医用与水热合成研究.

    冯守华, 吉林大学化学学院无机合成与制备化学国家重点实验室教授, 中国科学院院士. 主要从事无机固体化学、水热合成化学与原子级pn结材料的研究.

    庆祝《化学学报》创刊90周年.
  • 基金资助:
    项目受国家自然科学基金(21831003); 项目受国家自然科学基金(91959201)

Research Progress in the Application of Spinel Oxides in Tumor Therapy

Yuan Zhanga, Beining Zhengb, Meichun Fua, Shouhua Fenga()   

  1. a State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012
    b College of Physics, Jilin University, Changchun 130012
  • Received:2023-04-30 Published:2023-09-14
  • Contact: *E-mail: shfeng@jlu.edu.cn
  • About author:
    Dedicated to the 90th anniversary of Acta Chimica Sinica.
  • Supported by:
    National Natural Science Foundation of China(21831003); National Natural Science Foundation of China(91959201)

The spinel oxides have various elements, flexible cations, variable valence states and rich electronic structure, which bring about rich physical and chemical properties. In recent years, as important inorganic nano therapeutic agents in tumor, they had shown excellent potential in the field of tumor labeling, diagnosis and treatment. The ratio of A-O tetrahedron to B-O octahedron is fixed in the structure composition of spinel oxide AB2O4, and the occupancy ratio of eg orbital calculated by d orbital splitting in B-O octahedron can be used as a descriptor of various catalytic reactions. Therefore, it shows a unique advantage in establishing the structure-activity relationship between the electronic state structure of spinel oxides and the diagnostic and therapeutic performance in the treatment of various tumors.

Key words: spinel oxides, electronic state regulation, photothermal therapy, photodynamic therapy, reactive oxygen species catalysis