Research Progress on Delivery and Detection of Hydrogen Selenide in Vivo

doi:10.6023/A25110365

Acta Chimica Sinica ›› 2026, Vol. 84 ›› Issue (3): 448-458.DOI: 10.6023/A25110365 Previous Articles

Review

生物体内硒化氢气体递送及检测研究进展

莫秋红, 张峻, 尚品, 周怡波^*(), 卿志和

长沙理工大学化学与医药工程学院长沙 410000

投稿日期:2025-11-11 发布日期:2025-12-16

作者简介:

莫秋红, 2023年长沙理工大学在读硕士研究生, 主要从事有机小分子探针合成及其在生物化学传感与生物成像领域的应用.

张峻, 2025年长沙理工大学在读博士研究生, 主要从事聚合物信号放大探针的构建及其在生物化学传感与生物成像领域的应用.

尚品, 2024年长沙理工大学在读硕士研究生, 主要从事有机小分子荧光探针的构建及其在生物化学传感与生物成像领域的应用.

周怡波, 副教授, 硕士生导师, 长沙市杰青, 湖南省青年骨干教师. 2017年获湖南大学化学博士学位; 2018年至今工作于长沙理工大学, 2025年至英国巴斯大学化学系访问学者. 在Angew. Chem. Int. Ed.、Anal. Chem.、Biosens. Bioelectron等期刊发表论文30余篇. 获得湖南省自然科学二等奖、湖南省化学化工学会第十八届青年化学化工奖、湖南省优秀硕士学位论文指导教师等荣誉.

卿志和, 教授, 博士生导师, “国家优秀青年科学基金”获得者. 2014年获湖南大学化学博士学位; 2015年至今工作于长沙理工大学, 其间, 2019年至2020年于(加拿大)滑铁卢大学化学系访问学者. 从事化学生物传感与荧光成像研究, 相关成果发表在 PNAS、Angew. Chem.、Chem. Sci.、Anal. Chem.、 CCS Chem.等国内外高水平期刊上, 授权国家发明专利10余项. 担任Chin. Chem. Lett.、The Innovation、《分析试验室》等国内外期刊的编委或青年编委. 获得湖南省自然科学一等奖、湖南省青年科技奖、湖南省优秀研究生导师等.

基金资助:
项目受国家自然科学基金(22222402); 项目受国家自然科学基金(22474012); 湖南省自然科学基金(2024JJ3001); 湖南省自然科学基金(2025JJ50061); 长沙市杰出青年科学基金(kq2506009)

Research Progress on Delivery and Detection of Hydrogen Selenide in Vivo

Mo Qiuhong, Zhang Jun, Shang Pin, Zhou Yibo^*(), Qing Zhihe

School of Chemistry and Pharmaceutical Engineering, Changsha University of Science & Technology, Changsha 410000

Received:2025-11-11 Published:2025-12-16
Contact: *E-mail: yibozhou@163.com
Supported by:
National Natural Science Foundation of China(22222402); National Natural Science Foundation of China(22474012); Natural Science Foundation of Hunan Province(2024JJ3001); Natural Science Foundation of Hunan Province(2025JJ50061); Scientific and Technological Plan Project of Changsha of China(kq2506009)

Hydrogen selenide (H₂Se), recognized as the fourth endogenous gaseous neurotransmitter after NO, CO, and H₂S, plays a significant role in signal transduction. It is involved in various essential physiological processes, including antioxidant defense, cellular signal transduction, and regulation of gene expression. Additionally, H₂Se is vital for maintaining cellular redox balance and protecting cells from oxidative stress damage. Studies have shown that selenium is an essential trace element for the human body, and H₂Se is a key active substance produced during selenium metabolism. Its biological functions were similar as other gaseous signaling molecules, such as hydrogen sulfide, but it also exhibits unique chemical properties. However, the direct detection of H₂Se is challenging because of the high toxicity, extremely low stability, and rapid decomposition in aqueous solutions. To address these challenges, researchers are focused on developing donor molecules that remain stable under physiological conditions and release H₂Se via stimulation. In recent years, several novel H₂Se donors based on hydrolysis or nucleophilic substitution reactions have been reported. These compounds can gradually release H₂Se under specific conditions, thereby safely regulating its biological effects. Meanwhile, to monitor the dynamic fluctuation of H₂Se in living cells, a variety of highly selective and sensitive fluorescent probes have been developed, which were activated through specific chemical reactions at the recognition site. Experimental results have shown that the exogenous H₂Se donors rapidly distribute into the cytoplasm after entering the cells and significantly enhance the activity of intracellular antioxidant enzymes, such as glutathione peroxidase. Also, the H₂Se not only effectively eliminates excessive reactive oxygen species (ROS) and alleviates the cell damage caused by oxidative stress, but also exerts anti-inflammatory effects. This review primarily summarizes topics such as the synthesis and release mechanisms of H₂Se donors, detection of H₂Se, aiming to explore the future development prospects in the field of H₂Se.

Key words: hydrogen selenide, donor, biosensing, cell imaging

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Mo Qiuhong, Zhang Jun, Shang Pin, Zhou Yibo, Qing Zhihe. Research Progress on Delivery and Detection of Hydrogen Selenide in Vivo[J]. Acta Chimica Sinica, 2026, 84(3): 448-458.

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Fig. & Tab. 10

Scheme 1. Schematic of hydrogen selenide delivery and biosensing

Figure 1. (a) Synthesis of TDN1042; (b) Hydrolysis process of TDN1042[44] (Copyright 2019 Royal Society of Chemistry). Schematic of the reaction between (c) TDN1042 and (d) 2AP-PSe; (e) TOF-SIMS images of HeLa cells co-incubated with 2AP-PSe[45] (Copyright 2021 American Chemical Society)

Figure 2. (a) Schematic of cysteine-activated donor release of H2Se; (b) Schematic of the kinetic mechanism of Selenamide[46] (Copyright 2022 American Chemical Society). (c) Schematic of triggered H2Se donor universal platform and Its application in fluorescent donor; (d) Schematic of H2Se donor synthesis pathway and H2Se release mechanism[47] (Copyright 2024 American Chemical Society); (e) General FITA platform for developing H2Se-activated donors and analyte-replacement fluorescent probe[48] (Copyright 2025 American Chemical Society)

Figure 4. (a) Synthesis of H2Se donor; (b) The release mechanism of H2Se; (c) Schematic of the detection mechanism of H2Se[50] (Copyright 2024 Royal Society of Chemistry); (d) Synthesis of γ-ketoselenylether; (e) Schematic of the release mechanism of H2Se donors; (f) Comparison of various kinds of H2Se donors with different release rates[51] (Copyright 2024 Royal Society of Chemistry)

Figure 7. (a) Synthetic routes of Se-Hyd and Se-Acid and the release mechanism of H2Se; (b) Schematic diagram of the H2Se involved in signaling pathways in mice[54] (Copyright 2024 The Innovation Life)

Figure 8. (a) Synthesis and response mechanism of NIR-H2Se; (b) Selectivity and real time fluorescent response of NIR-H2Se to H2Se[69] (Copyright 2015 Royal Society of Chemistry); (c) The mesoporous silicon nanoprobe NIR-H2Se is used for the detection of H2Se[75] (Copyright 2018 American Chemical Society). (d) Response mechanism of Se-1 probe to H2Se; (e) Fluorescence confocal images of living cells under normoxic and hypoxic conditions[74] (Copyright 2015 Royal Society of Chemistry)

Figure 9. (a) Response mechanism of Hcy-H2Se toward H2Se; (b) Fluorescence confocal images of living cells incubated with Hcy-H2Se under normoxic and hypoxic conditions[70] (Copyright 2017 American Chemical Society). (c) Detection mechanism of HBT-Se; (d) Schematic diagram of HBT-Se paper-based sensor[71] (Copyright 2020 Elsevier)

References 78

[1]	Vrionis H. A.; Wang S.; Haslam B.; Turner R. J. Front. Mol. Neurosci. 2015, 2, 69.
[2]	Bothwell I. R.; Luo M. Org. Lett. 2014, 16, 3056. doi: 10.1021/ol501169y pmid: 24852128
[3]	Labunskyy V. M.; Hatfield D. L.; Gladyshev V. N. Physiol. Rev. 2014, 94, 739. doi: 10.1152/physrev.00039.2013
[4]	Atkins J. F.; Gesteland R. F. Nature 2000, 407, 463. doi: 10.1038/35035189
[5]	Carlisle A. E.; Lee N.; Matthew-onabanjo A. N.; Spears M. E.; Park S. J.; Youkana D.; Doshi M. B.; Peppers A.; Li R.; Joseph A. B.; Smith M.; Simin K.; Zhu L. J.; Greer P. L.; Shaw L. M.; Kim D. Nat. Metabolism 2020, 2, 603. doi: 10.1038/s42255-020-0224-7
[6]	Weekley C. M.; Harris H. H. Chem. Soc. Rev. 2013, 42, 8870. doi: 10.1039/c3cs60272a pmid: 24030774
[7]	Huang G.; Liu Y.; Zhu X.; He L.; Chen T. Exploration 2025, 247, 121031.
[8]	Hatfield D. L; Tsuji P. A.; Carlson B. A.; Gladyshev V. N. Trends Biochem. Sci. 2014, 39, 112. doi: 10.1016/j.tibs.2013.12.007 pmid: 24485058
[9]	Alim I.; Caulfield J. T.; Chen Y.; Swarup V.; Geschwind D. H.; Ivanova E.; Seravalli J.; Ai Y.; Sansing L. H.; SteMarie E. J.; Hondal R. J.; Mukherjee S.; Cave J. W.; Sagdullaev B. T.; Karuppagoounder S. S.; Ratan R. R. Cell 2019, 177, 1262. doi: 10.1016/j.cell.2019.03.032
[10]	Tian R.; Abarientos A.; Hong J.; Hashemi S. H.; Yan R.; Drager N.; Leng K.; Nalls M. A.; Singleton A. B.; Xu K.; Faghri F.; Kampmann M. Nat. Neurosci. 2021, 24, 1020. doi: 10.1038/s41593-021-00862-0
[11]	Fujita H.; Tanakn Y. K.; Ogata S.; Suzuki N.; Kuno S.; Barayeu U.; Akaike T.; Ogra Y.; Iwai K. Nat. Struct. Mol. Biol. 2024, 31, 1277. doi: 10.1038/s41594-024-01329-z
[12]	Ito J.; Nakamura T.; Toyama T.; Chen D.; Berndt C.; Poschmann G.; Mourao A. S. D.; Doll S.; Suzuki M.; Zhang W.; Zheng J.; Trumbach D.; Yamada N.; Ono K.; Yazaki M.; Kawai Y.; Arsiawa M.; Ohsaki Y.; Shirakawa H.; Wahida A.; Proneth B.; Saito Y.; Nakagawa K.; Mishima E.; Conrad M. Mol. Cell. 2024, 84, 4629. doi: 10.1016/j.molcel.2024.10.028
[13]	Ramakrishnan M.; Arivalagan J.; Satish L.; Mohan M.; Samuel Selvan Christyraj J. R.; Chandran S. A.; Ju H. J.; John L. A.; Ramesh T.; Ignacimuthu S.; Kalishwaralal K. Chemosphere 2022, 306, 135531. doi: 10.1016/j.chemosphere.2022.135531
[14]	Arthur J. R.; Mckenzie R. C.; Bckenzie G. J. J. Nutr. Health Aging. 2003, 133, 1457S.
[15]	Hu J.; Huang S.; Zhu L.; Huang W.; Zhao Y.; Jin K.; Zhuge Q. ACS Appl. Mater. Interfaces 2018, 10, 32988. doi: 10.1021/acsami.8b09423
[16]	Xu J.; Wang X.; Yin H.; Cao X.; Hu Q.; Lv W.; Xu Q.; Gu Z.; Xin H. ACS Nano 2019, 13, 8577. doi: 10.1021/acsnano.9b01798
[17]	Zhang Y.; Zou Z.; Liu S.; Chen F.; Li M.; Zou H.; Liu H.; Ding J. Asian J. Exp. Sci. 2024, 19, 18263.
[18]	Zhang Y.; Liu H.; Ding J. BME Front. 2024, 5, 0055. doi: 10.34133/bmef.0055
[19]	Lee X. R.; Xiang G. L. Clin. Neurol. Neurosurg. 2018, 173, 157.
[20]	Cao Z.; Liu J.; Yang X. Exploration 2024, 4, 0037.
[21]	Zhuo Z.; Wang H.; Zhang S.; Bartlett; P. F.; Walker T. L.; Hou S. T. J. Cereb. Blood Flow Metab. 2023, 43, 1060. doi: 10.1177/0271678X231156981
[22]	Wahlgren N.; Ahmed N.; Davalos A.; Hacke W.; Millan M.; Muir K.; Roine R. O.; Toni D.; Lees K. R. The Lancet. 2008, 372, 1303. doi: 10.1016/S0140-6736(08)61339-2
[23]	Blanco S.; Martinezlara E.; Siles E.; Peinado M. Á. Pharmaceutics 2022, 14, 1737. doi: 10.3390/pharmaceutics14081737
[24]	Hsu S. Y.; Chen C. H.; Mukda S.; Leu S. Antioxidants 2022, 11, 466. doi: 10.3390/antiox11030466
[25]	Bomer N.; Grote Beverborg N.; Hoes M. F.; Streng K. W.; Vermeer M.; Dokter M. M.; Ijmker J.; Anker S. D.; Cleland J. G. F.; Hillege H. L.; Lang C. C.; Ng L. L.; Samani N. J.; Tromp J.; Van Veldhuisen D. J.; Touw D. J.; Voors A. A.; Van Der Meer P. Eur. J. Heart Fail. 2019, 22, 1415. doi: 10.1002/ejhf.1644
[26]	Ai Mubarak A. A.; Van Der Meer P.; Bomer N. Curr. Heart Fail. Rep. 2021, 18, 122. doi: 10.1007/s11897-021-00511-4
[27]	Jun E.; Ye J.; Huang I.; Kim Y.; Lee H. Acta Virol. 2011, 55, 23. pmid: 21434702
[28]	Yang J.; Wang L.; Huang L.; Che X.; Zhang Z.; Wang C.; Bai L.; Liu P.; Zhao Y; Hu X.; Shi B.; Shen Y.; Liang X. J.; Wu C.; Xue X. Exploration 2021, 1, 61. doi: 10.1002/exp2.v1.1
[29]	Hoffmann P. R.; Berry M. J. Mol. Nutr. Food Res. 2008, 52, 1273. doi: 10.1002/mnfr.200700330 pmid: 18384097
[30]	Wang J.; Wang Z.; Li Y.; Hou Y.; Yin C.; Yang E.; Liao Z.; Fan C.; Martin L. L.; Sun D. Biomaterials 2023, 302, 148746.
[31]	Tao T.; Liu M.; Chen M.; Luo Y.; Wang C.; Xu T.; Jiang Y.; Guo Y.; Zhang J. H. Pharmacol. Ther. 2020, 4, 1594.
[32]	Rataan A. O.; Geary S. M.; Zakharia Y.; Rustum Y. M.; Salem A. K. Int. J. Mol. Sci. 2022, 23, 2215. doi: 10.3390/ijms23042215
[33]	Eng S.; Wang H.; Xin Y.; Zhao W.; Zhan M.; Li J.; Cai R.; Lu L. Nano Today 2021, 40, 101240. doi: 10.1016/j.nantod.2021.101240
[34]	Donner M. W.; Siddique T. Can. J. Chem. 2018, 96, 795. doi: 10.1139/cjc-2017-0637
[35]	Gannon S.; Chu A. F. J. Am. Coll. Cardiol. 2017, 69, 1811.
[36]	Minoshima M.; Reja S. I.; Hashimoto R.; Iijima K.; Kikuchi K. Chem. Rev. 2024, 124, 6198. doi: 10.1021/acs.chemrev.3c00549 pmid: 38717865
[37]	Tpaiero H.; Townseng D. M.; Tew K. D. Biomed. Pharmacother. 2003, 57, 134. doi: 10.1016/S0753-3322(03)00035-0
[38]	Shivakoti R.; Gupte N.; Yang W. T.; Mwelase N.; Kanyama C.; Tang A.; Pillay S.; Samaneka W.; Riviere C.; Berendes S.; Lama J.; Cardoso S.; Sugandhavesa P.; Semba R.; Christian P.; Campbell T.; Gupta A. Nutrients 2014, 6, 5061. doi: 10.3390/nu6115061 pmid: 25401501
[39]	Yao Y.; Pei F.; Kang P. Nutrition 2011, 27, 1095. doi: 10.1016/j.nut.2011.03.002
[40]	Wang L.; Yin J.; Yang B.; Qu C.; Lei J.; Han J.; Guo X. Biol. Trace Elem. Res. 2019, 194, 96. doi: 10.1007/s12011-019-01759-7
[41]	Wang X.; Wang S.; He S; Zhang F.; Tan W.; Lei Y.; Yu H.; Li Z.; Ning Y.; Xiang Y.; Guo X. Sci. China. C Life Sci. 2013, 56, 797. doi: 10.1007/s11427-013-4495-z
[42]	Shimada B. K.; Alfulaij N.; Seale L. A. Int. J. Mol. Sci. 2021, 22, 10713. doi: 10.3390/ijms221910713
[43]	Shi Y.; Yang W.; Tang X.; Yan Q.; Cai X.; Wu F. Front. Pediatr. 2021, 273, 120784.
[44]	Newton T. D.; Pluth M. D. Chem. Sci. 2019, 10, 10723. doi: 10.1039/C9SC04616J
[45]	Newton T. D.; Bolton S. G.; Garcia A. C.; Chouinard J. E.; Golledge S. L.; Zakharov L. N.; Pluth M. D. J. Am. Chem. Soc. 2021, 143, 19542. doi: 10.1021/jacs.1c09525
[46]	Kang X.; Huang H.; Jiang C.; Cheng L.; Sang Y.; Caim X.; Dongm Y.; Sun L.; Wen X.; Xi Z.; Yi L. J. Am. Chem. Soc. 2022, 144, 3957. doi: 10.1021/jacs.1c12006
[47]	Dong Y.; Liang W.; Yi L. J. Am. Chem. Soc. 2024, 146, 24776. doi: 10.1021/jacs.4c09215
[48]	Liang W.; Dong Y.; Yi L. Anal. Chem. 2025, 97, 16104. doi: 10.1021/acs.analchem.5c03272
[49]	Rong X.; Liu C.; Wang Y.; Zhao X.; Wang Z.; Zhu B. Sensors Actuators B: Chem. 2025, 428, 137263. doi: 10.1016/j.snb.2025.137263
[50]	Sarkar U. D.; Rana M.; Chakrapani H. Chem. Sci. 2024, 15, 19315. doi: 10.1039/d4sc05788k pmid: 39568918
[51]	Hankins R. A.; Carter M. E.; Zhu C.; Chen C.; Lukesh J. C. Chem. Sci. 2022, 13, 13094. doi: 10.1039/d2sc03533b pmid: 36425500
[52]	Pan X.; Song X.; Wang C.; Cheng T.; Luan D.; Xu K.; Tang B. Theranostics 2019, 9, 1794. doi: 10.7150/thno.31841
[53]	Li G.; Feng Z.; Hou Z.; Chen R.; Cui H.; Wang T.; Li P. Adv. Funct. Mater. 2024, 35, 2417681. doi: 10.1002/adfm.v35.12
[54]	Liu M.; Bu F.; Li G.; Xie W.; Xu H.; Wang X. Inova Life 2024, 2, 2424526.
[55]	Hankins R.; Lukesh J. Molecules 2024, 29, 3863. doi: 10.3390/molecules29163863
[56]	Kuganesan M.; Samra K.; Evans E.; Singer M.; Dyson A. Intensive Care Med. Exp. 2019, 7, 71. doi: 10.1186/s40635-019-0281-y pmid: 31845001
[57]	Rishi A.; Peyroche G.; Saveanu C.; Dauplais M.; Lazard M.; Beuneu F.; Decourty L.; Malabat C.; Jacquier A.; Blanquet S.; Plateau P. Plos one 2012, 7, e36343.
[58]	Kafle A.; Bhattarai S.; Miller J. M.; Handy S. T. RSC Adv. 2020, 73, 45180.
[59]	Niu P.; Liu J.; Rong Y.; Liu X.; Wei L. Tetrahedron 2021, 89, 132174. doi: 10.1016/j.tet.2021.132174
[60]	Zhu Y. W.; Ngowi E. E.; Tang A. Q.; Chu T.; Wang Y.; Shabani Z. I.; Paul L.; Jiang T.; Ji X. Y.; Wu D. D. Chem. Biol. Interact. 2025, 407, 111328. doi: 10.1016/j.cbi.2024.111328
[61]	Zhang J.; Su D.; Xue S; Li G.; Xu S.; Zhang Y. Eur. Food Res. Technol. 2025, 251, 829. doi: 10.1007/s00217-025-04671-8
[62]	Peng X.; Wang Z. Anal. Chem. 2019, 91, 10073. doi: 10.1021/acs.analchem.9b02006
[63]	You Z.; Winckelmann A.; Vogl J.; Recknagel S.; Abad C. Anal. Bioanal. Chem. 2024, 416, 3117. doi: 10.1007/s00216-024-05274-0
[64]	Vacchina V.; Dumont J. Selenoproteins 2018, 1661, 145.
[65]	Bagheri N.; Saraji M. Anal. Bioanal. Chem. 2019, 411, 7441. doi: 10.1007/s00216-019-02106-4 pmid: 31654101
[66]	Kim I. J.; Watson R. P.; Lindstrom R. M. Anal. Chem. 2011, 83, 3493. doi: 10.1021/ac200158e
[67]	Tian Y.; Zhang X. Sci. Sin. Chim. 2024, 54, 1817. doi: 10.1360/SSC-2024-0110
[68]	Zhang Y.; Jiang D.; Li J.; Wang J.; Liu K.; Liu J. Chin. J. Org. Chem. 2024, 44, 41 (in Chinese). doi: 10.6023/cjoc202305030
	(张莹珍, 江丹丹, 李娟华, 王菁菁, 刘昆明, 刘晋彪, 有机化学, 2024, 44, 41.) doi: 10.6023/cjoc202305030
[69]	Kong F.; Ge L.; Pan X.; Xu K.; Liu X; Tang B. Chem. Sci. 2016, 7, 1051. doi: 10.1039/C5SC03471J
[70]	Kong F.; Zhao Y.; Liang Z.; Liu X.; Pan X.; Luan D.; Xu K.; Tang B. Anal. Chem. 2016, 89, 688. doi: 10.1021/acs.analchem.6b03136
[71]	Xin F.; Tian Y.; Zhang X. Dyes Pigm. 2020, 177, 6890.
[72]	Liu T.; Pi H.; Chen B.; Zhang X. Acta Chim. Sinica 2024, 82, 1001 (in Chinese). doi: 10.6023/A24060181
	(刘童, 皮慧慧, 陈冰昆, 张小玲, 化学学报, 2024, 82, 1001.) doi: 10.6023/A24060181
[73]	Jiang L.; Chen Z.; Fan Y. Acta Chim. Sinica 2024, 82, 1069 (in Chinese). doi: 10.6023/A24070218
	(蒋励, 陈子晗, 凡勇, 化学学报, 2024, 82, 1069.) doi: 10.6023/A24070218
[74]	Tian Y.; Xin F.; Jing J.; Zhang X. J. Mater. Chem. B 2019, 7, 2829. doi: 10.1039/C8TB03169J
[75]	Hu B.; Cheng R.; Gao X.; Pan X.; Kong F.; Liu X.; Xu K.; Tang B. ACS Appl. Mater. Interfaces 2018, 10, 17345. doi: 10.1021/acsami.8b02206
[76]	Zhang C. X.; Wang H. P.; Liu M. Q.; Shen Y. M.; Gu B. Instrum. Anal. 2020, 39, 1494 (in Chinese).
	(张春香, 王慧平, 刘梦琴, 申有名, 谷标, 分析测试学报, 2020, 39, 1494.)
[77]	Kong Y.; Wu R.; Wang X.; Qin G.; Wu F.; Wang C.; Chen M.; Wang N.; Wang Q.; Cao D. RSC Adv. 2022, 12, 27933. doi: 10.1039/D2RA04549D
[78]	Han H. H.; Ge P. X.; Li W. J.; Hu X. L.; He X. P. Sensors 2025, 25, 1290. doi: 10.3390/s25051290

生物体内硒化氢气体递送及检测研究进展

Research Progress on Delivery and Detection of Hydrogen Selenide in Vivo

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[13]	Yang Bai, Ling-Wei Xue, Hai-Qiao Wang, Zhi-Guo Zhang. Research Advances on Benzotriazole-based Organic Photovoltaic Materials [J]. Acta Chimica Sinica, 2021, 79(7): 820-852.
[14]	Junhui Miao, Zicheng Ding, Jun Liu, Lixiang Wang. Research Progress in Organic Solar Cells Based on Small Molecule Donors and Polymer Acceptors [J]. Acta Chimica Sinica, 2021, 79(5): 545-556.
[15]	Min Lv, Ruimin Zhou, Kun Lu, Zhixiang Wei. Research Progress of Small Molecule Donors with High Crystallinity in All Small Molecule Organic Solar Cells [J]. Acta Chimica Sinica, 2021, 79(3): 284-302.