有机化学 ›› 2013, Vol. 33 ›› Issue (01): 174-177.DOI: 10.6023/cjoc201208039 上一篇    下一篇

研究简报

2,3,8,9-四氢吡啶并[2,3-d:6,5-d']二嘧啶-4,6-二酮衍生物的合成

杨留攀, 李加荣, 柴洪新, 袁洪, 张奇, 史大昕   

  1. 北京理工大学化工与环境学院 北京 100081
  • 收稿日期:2012-08-31 修回日期:2012-09-19 发布日期:2012-09-26
  • 通讯作者: 史大昕 E-mail:shidaxin@bit.edu.cn
  • 基金资助:

    北京理工大学研究生科技创新专项计划(No. 2011CX0436)资助项目.

Synthesis of 2,3,8,9-Tetrahydropyrido[2,3-d:6,5-d']dipyrimidine-4,6-diones

Yang Liupan, Li Jiarong, Chai Hongxin, Yuan Hong, Zhang Qi, Shi Daxin   

  1. School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081
  • Received:2012-08-31 Revised:2012-09-19 Published:2012-09-26
  • Supported by:

    Project supported by the Science and Technology Innovation Program of Beijing Institute of Technology (No. 2011CX0436).

以丙二腈、原羧酸三乙酯、吡啶为起始原料经环化、氨解, 然后与酮在甲醇钠催化下反应得到了2,3,8,9-四氢吡啶并[2,3-d:6,5-d']二嘧啶-4,6-二酮衍生物. 目标产物的结构经IR, NMR, ESI和元素分析确证.

关键词: 吡啶并二嘧啶二酮, 杂环化合物, 合成

2,3,8,9-Tetrahydropyrido[2,3-d:6,5-d']dipyrimidine-4,6-diones were synthesized by using malononitrile, ortho-triethyl and pyridine as starting materials in three steps reaction including cyclization, ammonolysis and reaction with ketones under the catalysis of sodium methoxide. The structures of the products were confirmed by NMR, IR, ESI and elemental analysis.

Key words: pyridodipyrimidinediones, heterocycle, synthesis