有机化学 ›› 2013, Vol. 33 ›› Issue (06): 1298-1303.DOI: 10.6023/cjoc201303016 上一篇    下一篇

研究论文

淫羊藿素的合成

牟关敏a, 蒲文臣b, 周敏b, 刘燕b, 杨海君a, 王淳b   

  1. a 西南科技大学材料学院 绵阳 621010;
    b 中国科学院成都生物研究所 成都 610041
  • 收稿日期:2013-03-12 修回日期:2013-04-14 发布日期:2013-04-17
  • 通讯作者: 杨海君 E-mail:yanghai_1976@163.com

Synthesis of Icaritin

Mu Guanmina, Pu Wenchenb, Zhou Minb, Liu Yanb, Yang Haijuna, Wang Chunb   

  1. a School of Materials and Science Engineering, Southwest University of Science and Technology, Mianyang 621010;
    b Natural Products Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041
  • Received:2013-03-12 Revised:2013-04-14 Published:2013-04-17

淫羊藿素是淫羊藿苷的苷元, 具有抗骨质疏松和调节雌激素等多种生物活性.以间苯三酚为原料, 经Houben- Hoesch反应、一锅法Algar-Flynn-Oyamada反应和铕促异戊烯基重排等8步反应实现了淫羊藿素的合成, 总收率4.2%.中间体及最终产物的结构均通过NMR和HRMS进行了表征.

关键词: 淫羊藿素, 黄酮醇, 异戊烯基, Algar-Flynn-Oyamada

Icaritin, the aglycone of icariin, has many pharmacological and biological activities, such as antiosteoporosis activity and estrogen regulation.The synthesis of caritin via an eight-step strategy including Houben-Hoesch acylation, one-pot Algar-Flynn-Oyamada reaction and europium-promoted prenylation etc., from anhydrous phloroglucin is reported in this paper.All the compounds were characterized by NMR and HRMS spectea.

Key words: icaritin, flavonols, isopentyl alkenyl, Algar-Flynn-Oyamada