有机化学 ›› 2014, Vol. 34 ›› Issue (3): 461-474.DOI: 10.6023/cjoc201309032 上一篇    下一篇

综述与进展

唾液酸衍生物的合成进展

王汝一a, 张姝b, 谭艳红a, 洪伟耀a, 成波a, 陈庆鑫a, 朱蕴韬a, 冯连顺a,c   

  1. a 北京大学化学与分子工程学院 北京 100871;
    b 谱尼测试科技股份有限公司 北京 100871;
    c 北京大学深圳研究生院化学生物学与生物技术学院 深圳 518055
  • 收稿日期:2013-09-23 修回日期:2013-11-10 发布日期:2013-12-06
  • 通讯作者: 冯连顺 E-mail:ochemistry@163.com
  • 基金资助:

    深圳市战略新兴产业发展专项资金(No. JCYJ20130329174913512);中国博士后科学基金面上(No. 2013M540013)资助项目.

Progress in the Synthesis of Sialic Acid Derivatives

Wang Ruyia, Zhang Shub, Tan Yanhonga, Hong Weiyaoa, Cheng Boa, Chen Qingxina, Zhu Yuntaoa, Feng Lianshuna,c   

  1. a Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871;
    b Pony Testing Co., Ltd., Beijing 100080;
    c School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055
  • Received:2013-09-23 Revised:2013-11-10 Published:2013-12-06
  • Supported by:

    Project supported by the Shenzhen Strategic Emerging Industrial Development Funds (No. JCYJ20130329174913512), and the China Postdoctoral Science Foundation (No. 2013M540013).

唾液酸是一类九碳糖,主要以糖脂或者糖蛋白的形式广泛分布于哺乳动物组织中,是脊椎动物细胞表面最重要的单糖. 唾液酸可修饰的位点较多,目前已发展出成千上万的非天然唾液酸衍生物用于分子成像. 尽管如此,非天然糖代谢工程方法还处于发展的初期,很多方面亟待发展和完善. 结合本课题组的研究成果,着重介绍了唾液酸衍生物的合成进展.

关键词: 唾液酸, 合成, 进展

Sialic acids, a family of more than 50 members of α-keto acidic monosaccharides with a 9-carbon backbone, are widely distributed in mammalian organisms in the form of glycolipids or glycoproteins. It is the most important monosaccharide appeared on the surface of cells of vertebrates. Nowadays, thousands of unnatural sialic acid derivatives have been synthesized for molecular imaging due to various modifiable sites in the sialic acid structure. However, metabolic oligosaccharide engineering (MOE), is still locating at its preliminary stage and requiring perfection urgently. Here, the research progress in the synthesis of sialic acid derivatives is reviewed.

Key words: sialic acid, synthesis, progress