手性缩醛的催化不对称合成研究进展

doi:10.6023/cjoc201503010

有机化学 ›› 2015, Vol. 35 ›› Issue (8): 1641-1649.DOI: 10.6023/cjoc201503010 上一篇下一篇

综述与进展

手性缩醛的催化不对称合成研究进展

杜鹏, 周海峰, 沈冠硕, 邹坤

三峡大学生物与制药学院天然产物研究与利用湖北省重点实验室宜昌 443002

收稿日期:2015-03-09 修回日期:2015-03-30 发布日期:2015-04-10
通讯作者: 周海峰 E-mail:haifeng-zhou@hotmail.com
基金资助:
国家自然科学青年基金(No. 21202092)和三峡大学人才科研启动基金(No. KJ2012B080)资助项目.

Catalytic Asymmetric Synthesis of Chiral Acetals

Du Peng, Zhou Haifeng, Shen Guanshuo, Zou Kun

Hubei Key Laboratory of Natural Products Research & Development, College of Biological & Pharmaceutical Sciences, China Three Gorges University, Yichang 443002

Received:2015-03-09 Revised:2015-03-30 Published:2015-04-10
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21202092) and the Startup Foundation from China Three Gorges University (No. KJ2012B080).

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摘要/Abstract

缩醛是许多药物和天然产物分子中常见的结构单元, 研究发现手性缩醛的生物活性通常优于其消旋体. 由于手性缩醛存在消旋化倾向, 其催化不对称合成具有挑战性, 近年来才引起关注. 综述了目前手性N,N-缩醛、N,O-缩醛、N,S-缩醛、O,O-缩醛的催化不对称合成研究进展, 及其在含缩醛骨架手性药物合成中的应用.

关键词: 手性缩醛, 催化不对称合成, 手性磷酸

Acetals are common building blocks of many drugs and natural product molecules. It was found that the biological activity of chiral acetals is usually superior to their racemates. The catalytic asymmetric synthesis of chiral acetals is challenge for its racemization and attracts attention until recent years. In this review, the recent studies on catalytic asymmetric synthesis of chiral aminals, N,O-acetals, N,S-acetals, O,O-acetals, as well as its application in synthesis of chiral drugs containing acetal moieties are reviewed.

Key words: chiral acetals, catalytic asymmetric synthesis, chiral phosphoric acid

引用此文

杜鹏, 周海峰, 沈冠硕, 邹坤. 手性缩醛的催化不对称合成研究进展[J]. 有机化学, 2015, 35(8): 1641-1649.

Du Peng, Zhou Haifeng, Shen Guanshuo, Zou Kun. Catalytic Asymmetric Synthesis of Chiral Acetals[J]. Chin. J. Org. Chem., 2015, 35(8): 1641-1649.

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手性缩醛的催化不对称合成研究进展

Catalytic Asymmetric Synthesis of Chiral Acetals

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