有机化学 ›› 2015, Vol. 35 ›› Issue (8): 1627-1640.DOI: 10.6023/cjoc201504003 上一篇    下一篇

综述与进展

Renieramycin类生物碱的合成研究进展

宋玉廷a, 胡玲玲a, 陈瑞蛟a,b, 陈小川a   

  1. a 四川大学化学学院 绿色化学与技术教育部重点实验室 成都 610064;
    b 济宁医学院 济宁 272067
  • 收稿日期:2015-04-01 修回日期:2015-04-22 发布日期:2015-05-06
  • 通讯作者: 陈小川 E-mail:chenxc@scu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 21172153, 21321061)、国家重点基础研究发展规划(973计划, No. 2010CB833200)资助项目.

Research Progress in Synthesis of Renieramycin-Type Alkaloids

Song Yutinga, Hu Linglinga, Chen Ruijiaoa,b, Chen Xiaochuana   

  1. a Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064;
    b Jining Medical College, Jining 272067
  • Received:2015-04-01 Revised:2015-04-22 Published:2015-05-06
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21172153, 21321061), the National Basic Research Program of China (973 Program, No. 2010CB833200).

具有显著抗癌、抗菌等活性的海洋四氢异喹啉生物碱引起多个领域的广泛关注, renieramycin型生物碱目前是其中成员数目最多的一类. 不少此类生物碱及衍生物显示纳摩尔级的抗癌活性, 加上有趣的分子结构, 使其成为有机合成研究的一个热点. 按合成策略分类, 概述了renieramycin型生物碱的全合成研究进展.

关键词: 四氢异喹啉, renieramycin生物碱, 天然产物, 全合成

Marine tetrahydroisoquinoline alkaloids have attracted much attention in the fields of chemistry, biology and medicine over the past forty years because of their remarkable antitumor and antimicrobial activities. Among them, renieramycins is a big group, which consists of renieramycins A~Y, jorunnamycins A~C and jorumycin. A number of renieramycins and their analogues showed nanomolar inhibitory effects in a panel of human tumor cell lines. Therefore, along with other tetrahydroisoquinoline antitumor antibiotics, renieramycins are one of hotspots in the synthetic study of natural products. Progresses on the synthesis of renieramycin-type alkaloids are reviewed in terms of the key strategies employed.

Key words: tetrahydroisoquinoline, renieramycin-type alkaloids, natural product, total synthesis