有机化学 ›› 2016, Vol. 36 ›› Issue (2): 352-357.DOI: 10.6023/cjoc201509026 上一篇    下一篇

研究论文

微波促进下含苯并杂环芳硫醚的合成

张变香, 杨丽花, 史瑞雪, 亢永强   

  1. 山西大学化学化工学院 太原 030006
  • 收稿日期:2015-09-21 修回日期:2015-10-14 发布日期:2015-10-26
  • 通讯作者: 张变香 E-mail:zbxthh@sxu.edu.cn
  • 基金资助:

    山西省科技创新项目(No. 2014101011)及山西大学本科生科研训练(No. 2014013)资助项目

Synthesis of Heterocyclic Aromatic Sulfides under Microwave Irradiation

Zhang Bianxiang, Yang Lihua, Shi Ruixue, Kang Yongqiang   

  1. School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006
  • Received:2015-09-21 Revised:2015-10-14 Published:2015-10-26
  • Supported by:

    Project supported by the Science and Technology Innovation Project of Shanxi Province (No. 2014101011) and the Undergraduate Research Training Program of Shanxi University (No. 2014013).

在微波辐射条件下, 通过巯基唑类化合物与芳基碘化物的反应, 得到了系列芳基硫醚化合物. 当微波输出功率为30 W、溶剂为N,N-二甲基甲酰胺(DMF)、反应时间为15 min时产率可达88%. 同时, 通过高效液相色谱分析法分别对微波辐射和传统油浴加热条件下的反应结果进行了讨论, 结果表明: 微波辐射条件下, 反应选择性高、时间短、副产物少. 此方法有望成为一种高效、温和、对环境友好的合成芳基硫醚的方法.

关键词: 巯基唑类化合物, 芳基碘化物, 芳基硫醚, 微波辐射, 高效液相色谱

The reaction of the thiolazole compounds with aryl iodide resulted in a series of aryl thioether compounds under microwave irradiation. It showed that the yield of target product was 88% when the reaction was carried out under microwave (30 W) heating for 15 min in N,N-dimethylformamide (DMF). The target products using microwave response and oil bath heating were tracked separately by high performance liquid chromatography (HPLC) analysis under the same conditions. The results showed that the method of microwave irradiation for the preparation of aryl sulfide was simple, efficient, time-saving and less by-products. It is expected to become an efficient, gentle and environmentally friendly synthetic method of heterocyclic aryl sulfides.

Key words: 2-mercaptobenzo heterocyclic, aryl iodide, aryl thioether, microwave irradiation, high performance liquid chromatography (HPLC)