有机化学 ›› 2017, Vol. 37 ›› Issue (7): 1855-1859.DOI: 10.6023/cjoc201701013 上一篇    下一篇

研究简报

CuSO4·5H2O/NaAsc催化下碘代芳烃和末端炔烃的Sonogashira偶联反应

戚海棠, 宋光琳, 权正军, 王喜存   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2017-01-05 修回日期:2017-02-22 发布日期:2017-03-14
  • 通讯作者: 王喜存, 权正军 E-mail:wangxicun@nwnu.edu.cn;quanzhengjun@hotmail.com
  • 基金资助:

    国家自然科学基金(Nos.21362032,21362031)资助项目.

CuSO4·5H2O/NaAsc-Catalyzed Sonogashira Coupling Reaction of Aryl Iodides and Terminal Alkynes

Qi Haitang, Song Guanglin, Quan Zhengjun, Wang Xicun   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2017-01-05 Revised:2017-02-22 Published:2017-03-14
  • Contact: 10.6023/cjoc201701013 E-mail:wangxicun@nwnu.edu.cn;quanzhengjun@hotmail.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21362032,21362031).

采用CuSO4·5H2O/NaAsc的均相催化体系,实现了碘代芳烃和末端炔烃的Sonogashira反应.此催化体系替代了一般的Pd/Cu结合磷配体的催化体系,具有催化剂廉价易得,后处理简单,反应在均相条件下进行等优点,符合绿色化学的要求.

关键词: 碘代芳烃, 末端炔烃, CuSO4·, 5H2O/NaAsc, Sonogashira偶联

In this paper, the homogeneous catalytic system of CuSO4·5H2O/NaAsc was used to realize the Sonogashira reaction of aryl iodides and terminal alkynes. This catalytic system replaces the general catalytic system of Pd/Cu-bound phosphorus ligand, which has the advantages of cheap catalyst, simple post-treatment, reaction under homogeneous conditions, and meets the requirements of green chemistry.

Key words: aryl iodides, terminal alkynes, CuSO4·, 5H2O/NaAsc, Sonogashira coupling