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有机化学
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有机化学 ›› 2017, Vol. 37 ›› Issue (6): 1582-1584.DOI: 10.6023/cjoc201701035 上一篇    下一篇

研究简报

三氟甲磺酸酯的高效合成(英文)

郑东青a,b, 马海燕b, 丁凯a   

  1. a. 中国科学院上海有机化学研究所 天然产物合成有机化学重点实验室 上海 200032;
    b. 华东理工大学化学系 上海 200237
  • 收稿日期:2017-01-18 修回日期:2017-01-20 发布日期:2017-01-20
  • 通讯作者: 马海燕,丁凯 E-mail:haiyanma@ecust.edu.cn;dingkai@mail.sioc.ac.cn
  • 基金资助:

    国家自然科学基金（No.20902098）资助项目.

A Practical Synthesis of Trifluoromethanesulfonate Esters

Zheng Dongqinga,b, Ma Haiyanb, Ding Kaia   

  1. a. CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    b. Department of Chemistry, East China University of Science and Technology, Shanghai 200237
  • Received:2017-01-18 Revised:2017-01-20 Published:2017-01-20
  • Contact: 10.6023/cjoc201701035 E-mail:haiyanma@ecust.edu.cn;dingkai@mail.sioc.ac.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20902098).

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补充材料

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原甲酸酯与三氟甲磺酸酐反应可高效合成三氟甲磺酸酯.该方法具有无需溶剂，反应条件温和，反应时间短，高产率，操作简单，底物范围广的特点.原位产生的试剂具有高的反应活性，可一锅法高产率制备三氟甲磺酸离子液体.

关键词: 三氟甲磺酸酯, 原酸酯, 三氟甲磺酸酐, 一锅法烷基化

A practical synthesis of trifluoromethanesulfonate esters by reaction of orthoformate esters with triflic anhydride is described. The solvent-free method featured mild condition, short time, high yield, simple operation and broad substrate scope. The in situ generated trifluoromethanesulfonate ester is highly reactive alkylating agent, providing triflate ionic liquid in excellent yield via a one-pot procedure.

Key words: trifluoromethanesulfonate ester, orthoester, triflic anhydride, one-pot alkylation