有机化学 ›› 2017, Vol. 37 ›› Issue (7): 1653-1666.DOI: 10.6023/cjoc201702017 上一篇    下一篇

综述与进展

硫肽类抗生素类似物合成进展

王守锋a,b, 郑庆飞c, 段盼盼c, 刘文c   

  1. a. 济南大学化学化工学院 济南 250022;
    b. 山东省氟化学化工材料重点实验室 济南 250022;
    c. 中国科学院上海有机化学研究所生命有机化学国家重点实验室 上海 200032
  • 收稿日期:2017-02-15 修回日期:2017-03-20 发布日期:2017-04-10
  • 通讯作者: 王守锋, 刘文 E-mail:chm_wangsf@ujn.edu.cn;wliu@sioc.ac.cn
  • 基金资助:

    国家自然科学基金(No.31430005)、山东省自然科学基金(No.ZR2016HM44)资助项目.

Progress in Synthesis of Thiopeptide Antibiotics Analogues

Wang Shoufenga,b, Zheng Qingfeic, Duan Panpanc, Liu wenc   

  1. a. College of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022;
    b. Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, University of Jinan, Jinan 250022;
    c. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032
  • Received:2017-02-15 Revised:2017-03-20 Published:2017-04-10
  • Contact: 10.6023/cjoc201702017 E-mail:chm_wangsf@ujn.edu.cn;wliu@sioc.ac.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.31430005) and the Natural Science Foundation of Shandong Province (No.ZR2016HM44).

硫肽类抗生素是一类富含硫元素且被高度修饰的聚噻(噁)唑多肽类天然产物,该家族化合物以其复杂的分子结构、良好的生物活性以及新颖的抗菌作用模式而成为研究热点.近年来,对于硫肽类抗生素类似物的合成研究发展迅速.综述了通过化学半合成、组合生物合成以及前体导向突变生物合成方法获得的硫肽类抗生素类似物的研究进展.

关键词: 硫肽类抗生素类似物, 化学半合成, 组合生物合成, 前体导向突变生物合成

Thiopeptide antibiotics, which are a growing class of sulfur-rich and highly modified polyazolyl peptide natural products, have been appreciated because of their complex structures, potent biological activities and unusual modes of action. Recently, a great deal of effort has been devoted to the development of various approaches for the efficient synthesis of thiopeptide antibiotics analogues. This review summarizes synthetic approaches towards thiopeptide antibiotics analogues via semisynthesis, combinatorial biosynthesis and precursor-directed mutasynthesis.

Key words: thiopeptide antibiotics analogue, semisynthesis, combinatorial biosynthesis, precursor-directed mutasynthesis