有机化学 ›› 2018, Vol. 38 ›› Issue (5): 983-998.DOI: 10.6023/cjoc201711046 上一篇    下一篇

综述与进展

氮唑并均三嗪类化合物的合成研究进展

汪涛, 谢中袍, 曾明, 崔冬梅   

  1. 浙江工业大学药学院 杭州 310014
  • 收稿日期:2017-11-28 修回日期:2018-01-08 发布日期:2018-01-26
  • 通讯作者: 崔冬梅,E-mail:cuidongmei@zjut.edu.cn E-mail:cuidongmei@zjut.edu.cn

Advances in the Synthesis of Nitrogen Zole s-Triazine Compounds

Wang Tao, Xie Zhongpao, Zeng Ming, Cui Dongmei   

  1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014
  • Received:2017-11-28 Revised:2018-01-08 Published:2018-01-26
  • Contact: 10.6023/cjoc201711046 E-mail:cuidongmei@zjut.edu.cn

氮唑并均三嗪类化合物具有抗增殖、抗氧化、抗病毒、抗肿瘤等多种生物活性,引起了药物化学家及相关工作者的特别关注,所以关于氮唑并均三嗪类化合物的合成方法成了研究热点.从四氮唑并均三嗪、三氮唑并均三嗪、二氮唑并均三嗪这三个方面综述了这类化合物的合成方法,最后对这类化合物合成方法中存在的问题进行了讨论,并对未来的发展进行了展望.

关键词: 氮唑, 均三嗪, 四氮唑并均三嗪, 三氮唑并均三嗪, 二氮唑并均三嗪

Nitrogen zole s-triazine derivatives display several biological activities such as antiproliferative, antioxidant, antiviral, antitumor and so on. Accordingly, much effort has been made towards the development of diverse synthetic methods for nitrogen zole s-triazines. The advancements in synthesis of nitrogen zole s-triazine compounds are summarized, including tetrazolo-s-triazines, triazolo-s-triazines and diazolo-s-triazines. At last the disadvantages of these synthetic methods are discussed and prospected to the future development.

Key words: nitrogen zole, s-triazine, tetrazolo-s-triazine, triazolo-s-triazine, diazolo-s-triazine