铱和手性硫脲串联催化的仲酰胺不对称还原氰基化和还原磷酰化反应

doi:10.6023/cjoc202100042

有机化学 ›› 2021, Vol. 41 ›› Issue (6): 2517-2519.DOI: 10.6023/cjoc202100042 上一篇下一篇

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铱和手性硫脲串联催化的仲酰胺不对称还原氰基化和还原磷酰化反应

李照坤(), 王晓明^*

中国科学院上海有机化学研究所金属有机化学国家重点实验室上海 200032

发布日期:2021-07-07
通讯作者: 王晓明

Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis

Zhaokun Li(), Xiaoming Wang

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Published:2021-07-07
Contact: Xiaoming Wang

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李照坤, 王晓明. 铱和手性硫脲串联催化的仲酰胺不对称还原氰基化和还原磷酰化反应[J]. 有机化学, 2021, 41(6): 2517-2519.

Zhaokun Li, Xiaoming Wang. Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis[J]. Chinese Journal of Organic Chemistry, 2021, 41(6): 2517-2519.

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图1. 含有手性α-腈基取代胺和α-膦酸取代胺的药物和天然产物示例

Figure 1. Representative pharmaceuticals and natural products containing chiral α-aminonitriles and α-aminophosphonic acids

图式1. 酰胺的还原官能团化

Scheme 1. Reductive functionalization of amides

图式2. 反应的底物范围示例

Scheme 2. Examples of the reaction scope

[1]	Fleming, F. F. Nat. Prod. Rep. 1999, 16,597.
[2]	Huang, P.-Q. Acta Chim. Sinica 2018, 76,357(in Chinese).
	(黄培强, 化学学报, 2018, 76,357.)
[3]	Matheau-Raven, D.; Gabriel, P.; Leitch, J. A.; Almehmadi, Y. A.; Yamazaki, K.; Dixon, D. J. ACS Catal. 2020, 10,8880.
[4]	Xu, Z.; Wang, X.-G.; Wei, Y.-H.; Ji, K.-L.; Zheng, J.-F.; Ye, J.-L.; Huang, P.-Q. Org. Lett. 2019, 21,7587.
[5]	Chen, D.-H.; Sun, W.-T.; Zhu, C.-J.; Lu, G.-S.; Wu, D.-P.; Wang, A. -.; Huang, P.-Q. Angew. Chem., Int. Ed. 2021, 60,8827.

铱和手性硫脲串联催化的仲酰胺不对称还原氰基化和还原磷酰化反应

Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis

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