有机化学 ›› 2021, Vol. 41 ›› Issue (9): 3400-3413.DOI: 10.6023/cjoc202103053 上一篇 下一篇
综述与进展
收稿日期:
2021-03-28
修回日期:
2021-06-01
发布日期:
2021-06-17
通讯作者:
焦鹏
作者简介:
基金资助:
Qihang Zhao, Longchang Tang, Peng Jiao()
Received:
2021-03-28
Revised:
2021-06-01
Published:
2021-06-17
Contact:
Peng Jiao
About author:
Supported by:
文章分享
1,1'-螺二氢茚骨架是在21世纪初发展起来的一类新型手性配体或催化剂的骨架, 具有C2对称性, 以及刚性强、稳定性高、易于修饰等特点. 周其林等将手性1,1'-螺二氢茚-7,7'-二酚(SPINOL)发展为一系列螺环配体及催化剂, 在催化不对称合成领域获得了巨大的成功. 1,1'-螺二氢茚骨架的配体及催化剂被认为是为数不多的“优势手性配体和催化剂”. 尽管催化的不对称合成已经出现, 目前方法得到的SPINOL及类似物多为外消旋体, 需要进行费力的手性拆分. 合成和拆分步骤繁琐的局限性对其大规模生产形成了阻碍. 因此, 如何从廉价易得的原料出发, 发展相应手性螺环骨架配体的高效、不对称催化合成新方法, 是非常迫切而且具有挑战性的课题. 总结了最近20年SPINOL及螺环骨架类似化合物的合成方法, 包括含杂原子的螺环骨架, 希望能对配体或催化剂用途的螺环骨架的构建有所启发.
赵启航, 唐珑畅, 焦鹏. 1,1'-螺二氢茚-7,7'-二酚(SPINOL)及类似物中螺环骨架的构建方法[J]. 有机化学, 2021, 41(9): 3400-3413.
Qihang Zhao, Longchang Tang, Peng Jiao. Construction of Spiro Skeletons in 2,2',3,3'-Tetrahydro-1,1'- spirobi[1H-indene]-7,7'-diol (SPINOL) and Analogues[J]. Chinese Journal of Organic Chemistry, 2021, 41(9): 3400-3413.
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