有机化学 ›› 2023, Vol. 43 ›› Issue (12): 4188-4212.DOI: 10.6023/cjoc202304009 上一篇    下一篇

综述与进展

具有avarane骨架结构的Dysidea属海绵来源的倍半萜醌/氢醌类天然产物的合成研究进展

荀稳a,*(), 蒋丽清a, 陈晓蕾a, 吴静纯a, 梁飞燕a, 邓懿楠a, 许波b,*()   

  1. a 肇庆学院食品与制药工程学院 广东肇庆 526061
    b 北京大学深圳研究生院化学生物与生物技术学院 广东深圳 518055
  • 收稿日期:2023-04-06 修回日期:2023-06-12 发布日期:2023-07-27
  • 基金资助:
    国家自然科学基金(22101011); 国家自然科学基金(22201245); 肇庆学院大学生创新创业训练计划(S202110580075)

Research Progress on the Synthesis of Sesquiterpene Quinones and Hydroquinones Natural Products with Avarane Skeleton from Dysidea sp.

Wen Xuna,*(), Liqing Jianga, Xiaolei Chena, Jingchun Wua, Feiyan Lianga, Yinan Denga, Bo Xub,*()   

  1. a School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, Guangdong 526061
    b School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, Guangdong 518055
  • Received:2023-04-06 Revised:2023-06-12 Published:2023-07-27
  • Contact: *E-mail: xun_wen@163.com;xu_bo@pku.edu.cn
  • Supported by:
    National Natural Science Foundation of China(22101011); National Natural Science Foundation of China(22201245); Training Program of the College Students Sci-Tech Innovation of Zhaoqing University(S202110580075)

将具有avarane骨架结构的Dysidea属海绵来源的倍半萜醌/氢醌类天然产物按照连接醌/氢醌部分和倍半萜部分的键的差异分为三类, 并以关键的合成策略为线索, 分别对目前已报道的这三类倍半萜醌/氢醌类天然产物的合成方法进行了较为详细的阐述, 期望能对其他天然产物的合成研究提供帮助.

关键词: 倍半萜醌/氢醌, Dysidea属海绵, avarane骨架, 合成策略

Sesquiterpene quinones and hydroquinones obtained from the marine sponge Dysidea sp. with avarane skeleton are classified into three categories based on the differences of the bond connecting the quinone/hydroquinone unit and the sesquiterpene unit. The reported synthetic methods for these three types of natural products are reviewed in detail based on their key synthetic strategies with the aim of assisting in the synthesis of other natural products.

Key words: sesquiterpene quinone/hydroquinone, marine sponge Dysidea sp., avarane skeleton, synthetic strategy