有机化学 ›› 2016, Vol. 36 ›› Issue (9): 2091-2104.DOI: 10.6023/cjoc201604034 上一篇    下一篇

综述与进展

Platencin(平板素)的全合成研究进展

刘楝a,b, 周淑晶a, 孙炳峰b   

  1. a 佳木斯大学药学院 佳木斯 154007;
    b 中国科学院上海有机化学研究所 中国科学院天然产物有机合成化学重点实验室 上海 200032
  • 收稿日期:2016-04-17 修回日期:2016-05-10 发布日期:2016-05-17
  • 通讯作者: 周淑晶, 孙炳峰 E-mail:bfsun@sioc.ac.cn;513587264@qq.com
  • 基金资助:

    国家自然科学基金(Nos.21172246,21290180,21472210)和中国科学院青年创新促进会(No.2012202)资助项目.

Progresses in Total Synthesis of Platencin

Liu Liana,b, Zhou Shujinga, Sun Bingfengb   

  1. a School of Pharmacy, Jiamusi University, Jiamusi 154007;
    b Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2016-04-17 Revised:2016-05-10 Published:2016-05-17
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21172246, 21290180, 21472210), and the Youth Innovation Promotion Association CAS (No.2012202).

Platencin是西班牙土壤样品中平板链球菌(Streptomyces platensis)MA7339的代谢产物,骨架具有6/6/6三环笼状结构,能够抑制细菌脂肪酸的生物合成,具有良好的广谱抗菌活性.综述了自2010年以来platencin的全合成以及形式合成的研究进展,对各个路线的反应步骤进行了说明,对合成策略进行了重点讨论.

关键词: platencin, 全合成, 合成策略

Platencin was isolated from a new strain of Streptomyces platensis MA7339 found in a soil sample collected in Spain. It has a novel molecular structure and exhibits a broad spectrum of antibacterial activity. In this review, the progresses since 2010 in the total synthesis of platencin are summarized with an emphasis on the synthetic strategies of the routes.

Key words: platencin, total synthesis, synthetic strategy