甲基乙二醛荧光探针的研究进展

doi:10.6023/cjoc202403003

摘要/Abstract

甲基乙二醛（MGO）作为一种高活性的羰基化合物,在生理和病理过程中起着重要作用。MGO作为糖基化剂可与蛋白质、DNA以及脂质反应形成晚期糖基化终产物（AGEs）,导致蛋白质功能障碍和细胞死亡,从而产生一系列疾病如心血管疾病、炎症、糖尿病等。因此,开发高效、快速、原位检测胞内MGO的方法尤为重要。荧光探针因其具有选择性好、灵敏度高、无侵入性等优势被广泛地运用于生物系统中MGO的检测。本综述总结了近年来MGO荧光探针的研究进展,对MGO荧光探针的设计思想、识别机理及其生物应用进行了重点阐述,并对MGO荧光探针的设计和应用前景提出了展望。

关键词: 甲基乙二醛, 活性碳基化合物, 晚期糖基化终末产物, 荧光探针

Methylglyoxal (MGO), as a highly active carbonyl compound, plays an important role in physiological and pathological processes. As a glycosylation agent, MGO can react with proteins, DNAs and lipids to form advanced glycation end products (AGEs), which lead to protein dysfunctions and cell death, and then cause a series of diseases such as cardiovascular disease, inflammation, diabetes and so on. Therefore, it is important to develop an efficient, rapid and in situ method for detecting intracellular MGO. Fluorescent probes have been widely used in the detection of MGO in biological systems due to their advantages of good selectivity, high sensitivity and non-invasiveness. In this review, the research progress on fluorescence probes of MGO is summarized and the design concept, recognition mechanism and biological application are emphasized in recent years. Finally, the prospect to design and applications of fluorescence probes for MGO is also discussed.

Key words: Methylglyoxal, Active carbonyl compounds, Advanced glycation end products, Fluorescent probes

引用此文

王雅萍, 范艳玲, 任咏琪, 徐玉林. 甲基乙二醛荧光探针的研究进展[J]. 有机化学, doi: 10.6023/cjoc202403003.

Wang Yaping, Fan Yanling, Ren Yongqi, Xu Yulin. Recent Progress on Fluorescent Probes for the Detection of Methylglyoxal[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202403003.

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