钯催化烯烃的不对称氢酯基化反应研究进展

doi:10.6023/cjoc202509035

摘要/Abstract

不对称氢酯基化反应因其原子经济性和步骤简洁性,已成为合成手性羧酸衍生物最具吸引力的途径之一。该反应的核心挑战在于同时实现高化学、区域与对映体选择性的协同调控,而手性配体作为催化体系的关键组分,通过精准调控过渡金属活性中心的立体电子特性及配位环境,可以直接主导反应的催化效率与立体化学调控。本综述系统梳理了数十年来钯催化烯烃的不对称氢酯基化反应研究进展,同时评述了手性配体的创新设计对选择性控制的突破性贡献,并展望了该领域面临的挑战与未来发展方向。

关键词: 手性配体, 不对称, 氢酯基化, 钯催化

Asymmetric hydroesterification has become one of the most attractive pathways for synthesizing chiral carboxylic acid derivatives due to its atom economy and step simplicity. The core challenge of this reaction lies in the simultaneous achievement of synergistic control over high chemo-, regio-, and enantioselectivity. Chiral ligands, as key components of the catalytic system, directly govern the catalytic efficiency and stereochemical control of the reaction by precisely modulating the stereoelectronic properties and coordination environment of the transition metal active center. This review systematically summarizes the research progress over decades in palladium-catalyzed asymmetric hydroesterification of alkenes, critically evaluates the breakthrough contributions of innovative chiral ligand design to selectivity control, and discusses the challenges and future development directions in this field.

Key words: chiral ligands, asymmetric, hydroesterification, palladium-catalyzed

引用此文

冯凯, 贺兆波, 王震. 钯催化烯烃的不对称氢酯基化反应研究进展[J]. 有机化学, doi: 10.6023/cjoc202509035.

Feng, Kai, He, ZhaoBo, Wang, Zhen. Recent Advances in Palladium-Catalyzed Asymmetric Hydroesterification of Alkenes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202509035.

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