关键词: α,β-不饱和γ-内酯, α,β-不饱和γ-内酰胺, 不对称催化

Optically active α,β-unsaturated γ-lactone and γ-lactam serve as core scaffolds in numerous natural products. These natural products exhibit a broad spectrum of bioactivities, making them highly significant for the development of novel drugs. Furthermore, as an important class of chiral building blocks, optically active α,β-unsaturated γ-lactone and γ-lactam play a pivotal role in synthesizing diverse bioactive compounds and complex molecules. Given their versatile biological activities and potential for structural diversification, the construction of such frameworks via asymmetric catalytic synthesis has received much attention from the academic community. This review summarizes the recent advances in asymmetric catalytic methods for synthesizing α,β-unsaturated γ-lactone and γ-lactam employing transition metal catalyst, Lewis acid catalyst and organo- catalyst, and discusses the stereocontrol mechanism in representative examples and the related application value.

Key words: α,β-unsaturated γ-lactone, α,β-unsaturated γ-lactam, asymmetric catalysis