可见光介导钌催化苯胺衍生物对位酰基化和二氟烷基化

doi:10.6023/cjoc202604018

摘要/Abstract

本文开发了一种可见光介导的钌催化苯胺衍生物对位C-H酰基化及二氟烷基化方法。该策略避免了传统方法中的高温条件且具有良好的官能团耐受性。苯胺芳环上的取代基电性会影响反应的方向（酰基化vs二氟烷基化）。机理研究表明,钌催化剂首先被还原为零价钌,从而进行催化循环。酰基化的关键路径涉及二氟甲基化中间体的顺序脱氟与亲核加成过程。

关键词: 可见光介导, 钌催化, 对位酰基化, 对位二氟烷基化

Herein, a visible light-mediated ruthenium-catalyzed method for the para-C-H acylation and difluoroalkylation of aniline derivatives is developed. This strategy avoids the high-temperature conditions required by traditional methods and exhibits good functional group tolerance. The electronic nature of the substituents on the aniline aromatic ring influences the reaction direction (acylation vs difluoroalkylation). Mechanistic studies suggest that the ruthenium catalyst is first reduced to Ru(0), which then enters the catalytic cycle. The key pathway of acylation involves sequential defluorination and nucleophilic addition processes.

Key words: visible-light-mediated, ruthenium catalysis, para-acylation, para-difluoroalkylation

引用此文

易千禧, 梁宸伟, 程瑶航, 安光辉. 可见光介导钌催化苯胺衍生物对位酰基化和二氟烷基化[J]. 有机化学, doi: 10.6023/cjoc202604018.

Yi Qianxi, Liang Chenwei, Cheng Yaohang, An Guanghui. Visible-Light-Mediated Ruthenium-Catalyzed Para-Acylation and Difluoroalkylation of Aniline Derivatives[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202604018.

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