关键词: 锆氢化, 环氧化物, 氢化铝锂, 选择还原

Epoxides undergo hydrozirconation under mild conditions. The reaction intermediates, alkoxylbis(cyclopentadienyl)zirconium chlorides, are easily decomposed by moisture. The hydrozirconation of epoxides to alcs. shows high regioselectivity which can exceed 92% for aromatic epoxides. In contrast to LiAlH4, the results of hydrozirconation of epoxides to alcs. are similar to electrophilic metal hydride reduction, which gives predominantly less substituted alcs. Addition of Cp2MCl2 (M = Ti, Zr), or Ti(OBu)4 improved the regioselectivity of hydrozirconation but decreased the regioselectivity with LiAlH4.

Key words: HYDROZIRCONATION, EPOXIDE, ALUMINIUM LITHIUM HYD, SELECTIVE REDUCTION