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有机化学
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有机化学 ›› 1994, Vol. 14 ›› Issue (1): 87-90. 上一篇    下一篇

研究论文

雌甾-4,9-二烯衍生物的A环芳构化反应

苏何东;李振肃   

  1. 北京医科大学药学院
  • 发布日期:1994-02-25

The ring-a aromatization of estradiene derivative

LI ZHENSU   

  • Published:1994-02-25

研究了11β-羟基或11β-甲氧基雌甾-4,9-二烯衍生物A环芳构化反应, 我们发现在质子溶剂中,酸催化能促进雌甾二烯衍生物转变成雌甾-1,3,5(10),9(11)-四烯.推测反应经过一个雌甾-4,9,11-三烯-3,17-二酮中间体机理. 这一机理通过进一步研究部分得到证实.碘同样可以催化这种芳构化.

关键词: 雌激素, 国家教委高等学校博士学科点专项科研基金, 雌甾-4,9-二烯 P, 芳构化反应

The ring-a aromatization of 11β-hydroxyl or 11β-methoxyl estra-4,9-diene derivatives was studied. It was found that these estradiene derivatives would give rise to estra-1,3,5-(10), 9(11)-tetraens when treated with acidic catalyst in protonic solvents. A estra-4,9,11-trene-3,17- dione intermediate mechanism was suggested and partly confirmed by further investigation. The aromatization process can also be catalyzed by Iodine.

Key words: ESTROGEN

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