有机化学 ›› 1996, Vol. 16 ›› Issue (5): 403-414. 上一篇    下一篇

研究论文

Corey化学酶与不对称合成

聂爱华;叶秀林   

  1. 北京大学化学系
  • 发布日期:1996-10-25

Corey's chemzyme and asymmetric synthesis

NIE AIHUA;YE XIULIN   

  • Published:1996-10-25

本文从立体化学和反应机理方面综述了Corey化学酶的催化作用及其在有机不对称合成中的应用, 指出了Corey化学酶与酶的相同点和不同点, 对于关键的反应过程态均以空间关系更为清楚的构象式表示。

关键词: 胺 P, 化学酶, 催化作用, 不对称反应

This review examines the catalysis and application of Corey's chemzyme in asymmetric organic synthesis from the viewpoint of stereochemistry and reaction mechanism. The similarities and differences between chemzyme and enzyme are shown clearly in the paper. In order to give more clear the spacial relationship some key transient states are described by the comformational formula.

Key words: CATALYTIC EFFECT, PROPANAMINE P

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