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有机化学
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有机化学 ›› 1998, Vol. 18 ›› Issue (5): 456-461. 上一篇    下一篇

研究论文

2-氨基-3-羟基环戊烯-1-腈衍生物的合成和晶体结构

史达清;屠树江;高原;戴桂元   

  1. 徐州师范大学化学系.徐州(221009)
  • 发布日期:1998-10-25

Synthesis and crystal structure of 2-amino-3- hydroxycyclopentene-1- carbonitrile derivatives

Shi Daqing;Tu Shujiang;Gao Yuan;Dai Guiyuan   

  1. Xuzhou Teachers Coll, Dept Chem.Xuzhou(221009)
  • Published:1998-10-25

被引次数

1 | 1

用低价钛试剂(TiCl~4-Zn)与α,α-(4-氯苯基)(二氰甲基)甲基苯基酮反应合成了非对映消旋体(3R,5S;3S,5R)和(3R,5R;3S,5S)2-氨基-3-羟基-3-苯基-5-对氯苯基环戊烯-1-腈。并用X射线衍射分析确定了这两个非对映异构体的构型。

关键词: 环戊烯P, 氨基腈, 氯化钛, 晶体结构, 合成, 二苯乙醇酮P, 钛试剂, 氯苯P, 构型, 环烯腈

The diastereomeric racemates (3R, 5S; 3S, 5R) and (3R, 5R; 3S, 5S) 2- amino-3-hydroxy-3-phenyl-5-(4'-chlorophenyl) cyclopentene-1- carbonitriles were synthesized by reaction of low-valent titanium reagent (TiCl~4-Zn) with α, α-(4-chlorophenyl) (dicyanomethyl) methyl phenyl ketone. Their configurations were determined by X-ray analysis.

Key words: TITANIUM CHLORIDE, CYCLOPENTENE P, DIPHENYLHYDROXYETHANONE P, SYNTHESIS, CHLOROBENZENE P, CONFIGURATION, TIRON, AMINONITRILE, CRYSTAL STRUCTURE, DIMETHYL-OCTAHYDRO-NAPHTHANITRILE

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