有机化学 ›› 1999, Vol. 19 ›› Issue (3): 242-248. 上一篇    下一篇

研究论文

交联酶晶体的性能及其在有机合成中的应用

李祖义;朱伟   

  1. 中国科学院上海有机化学研究所.上海(200032)
  • 发布日期:1999-06-25

The properties and application of cross-linked enzyme crystals in organic synthesis

Li Zuyi;Zhu Wei   

  1. Shanghai Inst Organ Chem., CAS.Shanghai(200032)
  • Published:1999-06-25

交联酶晶体提供了酶(高活性,高选择性,易处理,反应条件温和)及固相催化剂(环境适应性大,能循环利用)的复合特征。它在稳定性、活性、机械强度方面均有突出的优势。交联酶晶体在有机合成中非常有用,如在手性化合物拆分,肽合成,及碳-碳键的形成等方面有着比较成功的应用。

关键词: 肽, 应用, 有机合成, 交联酶晶体, 消旋体拆分, 活性, 性能, 稳定性

Cross-Linked Enzyme Crystals (CLEC) offer a combination of the features normally associated with either enzymes (high activity and selectivity, ability to function under mild reaction conditions, ease of disposal) or heterogeneous catalysts (stability in different environments, recycling). CLEC has the excellent stability, activity, mechanical strength. CLEC catalysts are extremely useful in organic synthesis, especially in the resolution of chiral compounds, peptides synthesis, and the formation of C-C bonds.

Key words: PROPERTIES, ORGANIC SYNTHESIS, MESOTOMY, STABILITY, APPLICATION, ACTIVITY, PEPTIDE

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