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有机化学
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有机化学 ›› 2001, Vol. 21 ›› Issue (1): 56-59. 上一篇    下一篇

研究论文

柔弱短指软珊瑚Sinularia Tenella Li. 中西松烯二萜内酯成分 研究

林翠梧;苏镜娱;曾陇梅;戚穗坚;彭文烈;徐安龙   

  1. 中山大学化学化工学院;中山大学生命科学学院
  • 发布日期:2001-01-25

Studies on the cembranoid diterpenes of sinularia tenella Li.

Lin Cuiwu;Su Jingyu;Zeng Longmei;Qi Suijian;Peng Wenlie;Xu Anlong   

  • Published:2001-01-25

PDF

417

被引次数

13 | 2

首次报道柔弱短指软珊瑚(SinulariatenellaLi.)的化学成分。从中国南海采集的柔弱短指软珊瑚中分离得到5个西松烯二萜内酯。根据波谱数据分析，推导出它们的结构：dihydroflexibilide(1),flxibilide(2)sinulariolide(3),(1R,4R,5R,8S,9S,12S,13S)-9-acetoxy-5,8:12,13-diepoxy-cembr-15(17)-en-16,4(olide(4)和(1R,4R,5S12S,13S)-5-acetoxy-12,13-epoxy-cembr-8E,15(17)-dien-16,3-olide(5)。还利用1^H-1^HCOSY,HMQC,HBMC二维谱首次对dihydroflexibilide(1)所有的1^HNMR和13^CNMR信号归属作了指定。测定了1、2和3的细胞毒性。

关键词: 柔弱短指软珊瑚, 西松烯二萜内酯, 二维核磁共振谱法, 化学成分, 细胞毒性试验, 内酯衍生物, 二萜烯生物碱, 软珊瑚

The chemical constituents of marine soft coral Sinularia tenella Li. collected from Hainan Sanya are reported herein for the first time. Five cembrenolides, i. e., dihydroflexibilide, flxibilide, sinulariolide, (1R, 4R, 5R, 8S, 9S, 12S, 13)-9-acetoxy- 5,8:12,13- diepoxy-cembr-15(17)-en-16,4-olide and (1R, 4R, 5S, 12S, 13S)-5- acetoxy-12,13-epoxy-cembr-8E,15(17)-dien-16,3-olide were isolated and identified by means of spectroscopic method. Base on the 1^H-1^H COSY, HMQC and HBMC experiments, all the 1^H NMR and the 13^C NMR signals of dihydroflexibilide were assigned for the first time in this paper.

Key words: 2D NMR SPECTROMETRY, CHEMICAL COMPOSITION, CYTOTOXICITY TEST, LACTONE DERIVATIVE, DITERPENE ALKALOID, SOFT CORAL

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