接骨木属植物的化学成分研究进展

doi:10.6023/cjoc201204025

摘要/Abstract

接骨木属植物具有很好的药用价值, 其根皮和果实多可入药. 对近20年从该属植物中分离得到的黄酮、三萜、环烯醚萜苷、酚及酚苷、木脂素、氰苷等成分进行综述, 并简要介绍接骨木属植物抑制HIV逆转录、抗病毒、消炎、镇痛等活性, 并对接骨木属植物的药用前景进行展望.

关键词: 接骨木, 化学成分, 生物活性, 保健作用

The plants of Sambucus L. have good medical values, most of the roots and fruits can be used as medicine. In this review, the constituents including flavones, triterpenes, iridoid glycosides, phenols and phenolic glycosides, lignans, cyanophoric glycosides being covered during the recent twenty years are summarized. The inhibitory action of HIV-RT, antivirus, antiphlogosis, and labor pain activities are introduced in brief. On this basis, the medicine prospections of Sambucus L. are also prospected.

Key words: Sambucus L., chemical constituents, bioactivity, health care function

引用此文

马养民, 吴昊. 接骨木属植物的化学成分研究进展[J]. 有机化学, 2012, 32(11): 2063-2072.

Ma Yangmin, Wu Hao. Chemical Constituents of Sambucus L.[J]. Chin. J. Org. Chem., 2012, 32(11): 2063-2072.

导出引用 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

分享此文

参考文献

[1] Chinese Academy of Science Flora of China Editorial Board Flora of China, Vol. 72, Science Press, Beijing, 1988, p. 5 (in Chinese).
(中国科学院中国植物志编辑委员会, 中国植物志, 72卷科学出版社, 北京, 1988, p. 5.)
[2] The Chinese Academy of Science Northwest Institute of Botany Flora of Qinling, Science Press, Beijing, 1978, p. 29 (in Chinese).
(中国科学院西北植物研究所, 秦岭植物志, 科学出版社, 北京, 1978, p. 29.)
[3] Zhao, J.-F.; Zhou, G.-F. Chin. Med. J. Metall. Ind. 2010, 27, 398 (in Chinese).
(赵京芬, 周广芬, 中国冶金工业医学杂志, 2010, 27, 398.)
[4] Gao, J.-M. Phytochemistry, Science Press, Beijing, 2003, pp. 142～143 (in Chinese).
(高锦明, 植物化学, 科学出版社, 北京, 2003, pp. 142～143.)
[5] Wu, X.; Cao, G.; Prior, R.-L. J. Nutr. 2002, 132, 1865.
[6] Lamaison, J. L.; Petitjean-Freytet, C.; Carnat, A. Ann. Pharm. Fr. 1991, 49, 258.
[7] Wei, C.-Y.; Xu, C.-F.; Luo, W.-Y.; Li, X.-G. J. Jinlin Agric. Univ. 1999, 21, 7 (in Chinese).
(魏春雁, 徐崇范, 罗维莹, 李向高, 吉林农业大学学报, 1999, 21, 7.)
[8] Tang, L.-Y.; Luo, M.-H.; Jiang, N.; Lin, H.-H. J. Chin. Med. Mater. 2007, 30, 549 (in Chinese).
(唐柳怡, 罗明华, 蒋宁, 林宏辉, 中药材, 2007, 30, 549.)
[9] Liao, Q.-F.; Xie, S.-P.; Chen, X.-H.; Bi, K.-S. J. Chin. Med. Mater. 2006, 29, 916 (in Chinese).
(廖琼峰, 谢社平, 陈晓辉, 毕开顺, 中药材, 2006, 29, 916.)
[10] Roschek, B. Jr.; Fink, R. C.; McMichael, M. D.; Li, D.; Alberte, R. S. Phytochemistry 2009, 70, 1255.
[11] Pinto, L. H.; Lamb, R. A. J. Biol. Chem. 2006, 281, 8997.
[12] D'Abrosca, B.; DellaGreca, M.; Fiorentino, A.; Monaco, P.; Previtera, L.; Simonet, A. M.; Zarrelli, A. Phytochemistry 2001, 58, 1073.
[13] Pietta, P.; Bruno, A. J. Chromatogr. 1992, 593, 165.
[14] Dawidowicz, A. L.; Wianowska, D.; Baraniak, B. Food Sci. Technol. 2006, 39, 308.
[15] Bonerz, D.; Würth, K.; Dietrich, H. Eur. Food Res. Technol. 2006, 224, 355.
[16] Brambilla, A.; Loscalzo, R.; Bertolo, G.; Torreggiani, D. J. Agric. Food Chem. 2008, 56, 2643.
[17] Lata, B.; Tomala, K. J. Agric. Food Chem. 2007, 55, 10795.
[18] Nakajima, J.-I.; Seo, S.; Yamozaki, M.; Saito, K. J. Biomed. Biotechnol. 2004, 5, 241.
[19] Bridle, P.; Timberlake, C. F. Food Chem. 1997, 58, 103.
[20] Castañeda-Ovando, A.; Pacheco-Hernández, M. L.; Páez- Hernández, M. E.; Rodríguez, J. A.; Galán-Vidal, C. A. Food Chem. 2009, 113, 859.
[21] Nakatani, N.; Kikuzaki, H.; Hikida, J.; Ohba, M.; Inami, O.; Tamura, I. Phytochemistry 1995, 38, 755.
[22] Saito, N.; Tatsuzawa, F.; Yoda, K.; Yokoi, M.; Kasahara, K.; Iida, S.; Shigihara, A.; Honda, T. Phytochemistry 1995, 40, 1283.
[23] Bridle, P.; García-Viguera, C. Food Chem. 1997, 59, 299.
[24] Seeram, N. P.; Momin, R. A.; Nair, M. G.; Bourquin, L. D. Phytomedicine 2001, 8, 362.
[25] Veberic, R.; Jakopic, J.; Stampar, F.; Schmitzer, V. Food Chem. 2009, 114, 511.
[26] Jordheim, M.; Giske, N. H.; Andersen, ø. M. Biochem. Syst. Ecol. 2007, 35, 153.
[27] Schwaiger, S.; Zeller, I.; Pölzelbauer, P.; Frotschnig, S.; Laufer, G.; Messner, B.; Pieri, V.; Stuppner, H.; Bernhard, D. J. Ethnopharmacol. 2011, 133, 704.
[28] Guo, X.-M.; Zhang, L.; Quan, S.-C.; Hong, Y.-F.; Liu, M.-Z. Chin. Trad. Herb. Drugs 1998, 29, 727 (in Chinese).
(郭学敏, 章岭, 全山丛, 洪永福, 刘明珠, 中草药, 1998, 29, 727.)
[29] Yang, X.-J.; Wang, N.-L.; Huang, W.-X.; Chen, X.-Z.; Yao, X.-S. J. Shenyang Pharm. Univ. 2005, 6, 449 (in Chinese).
(杨序娟, 王乃利, 黄文秀, 陈新滋, 姚新生, 沈阳药科大学学报, 2005, 6, 449.)
[30] Leung, K.; Rajkovic, I. A.; Peters, E. Endocrinology 1996, 137, 2694.
[31] Li, K.-Q.; Chen, W.; Zhang, S.-L.; Ye, W.-F.; Liu, Y.-L.; Leng, G.-H. Chin. Trad. Pat. Med. 2003, 25, 356 (in Chinese).
(李开泉, 陈武, 张绍良, 叶文峰, 刘艳凌, 冷桂华, 中成药, 2003, 25, 356.)
[32] Chen, W.; Li, K.-Q.; Xiong, X.-J.; Zhang, J.-H.; Zhu, J.-X.; Liu, C.-A. J. Nanchang Univ. (Nat. Sci.) 2001, 25, 165 (in Chinese).
(陈武, 李开泉, 熊筱娟, 张建慧, 朱建新, 刘传安, 南昌大学学报(理科版), 2001, 25, 165.)
[33] Ma, X.-H. Acta Pharm. Sin. 1982, 17, 93 (in Chinese).
(马学惠, 药学学报, 1982, 17, 93.)
[34] Yang, Y.-J.; Lin, J.-H. J. Chin. Med. Mater. 2004, 27, 491 (in Chinese).
(杨燕军, 林洁红, 中药材, 2004, 27, 491.)
[35] Sasaki, T.; Li, W.; Morimura, H.; Li, S.; Li, Q.; Asada, Y.; Koike, K. Chem. Pharm. Bull. 2011, 59, 1396.
[36] Han, M.-H. M. S. Thesis, Heilongjiang University of Traditional Chinese Medicine, Harbin, 2003 (in Chinese).
(韩美华, 硕士论文, 黑龙江中医药大学, 哈尔滨, 2003.)
[37] Ouyang, F.; Liu, Y.; Li, R.; Li, L.; Wang, N.-L.; Yao, X.-S. Chin. J. Nat. Med. 2011, 9, 26.
[38] Zhang, D.-M. Phenolic Acidic Chemistry, Chemical Industry Press, Beijing, 2009, p. 1 (in Chinese).
(张东明, 酚酸化学, 化学工业出版社, 北京, 2009, p. 1.)
[39] Yang, X.-J.; Huang, W.-X.; Wang, N.-L.; Chen, X.-Z.; Yao, X.-S. Chin. Trad. Herb. Drugs 2005, 36, 1604 (in Chinese).
(杨序娟, 黄文秀, 王乃利, 陈新滋, 姚新生, 中草药, 2005, 36, 1604.)
[40] Peng, L. H.; Ko, C. H.; Siu, S. W.; Koon, C. M.; Yue, G. L.; Cheng, W. H.; Lau, T. W.; Han, Q. B.; Ng, K. M.; Fung, K. P.; Lau, C. B. S.; Leung, P. C. J. Ethnopharmacol. 2010, 131, 82.
[41] Shen, X.-Y.; Wei, Y.; Yang, X.-S.; Yang, B.; Tong, L.-H.; Hao, X.-H. Nat. Prod. Res. Dev. 2006, 2, 249 (in Chinese).
(沈笑媛, 危英, 杨小生, 杨波, 佟丽华, 郝小红, 天然产物研究与开发, 2006, 2, 249.)
[42] Chen, X.-Z.; Li, G.-Y.; Wu, X.-Q.; Huang, Q.-C.; Zhang, G.-L. Chin. J. Appl. Environ. Biol. 2010, 16, 197.
[43] Liu, C.-A.; Zou, S.-Q. J. Anhui Agric. Sci. 2005, 33, 2334 (in Chinese).
(刘传安, 邹盛勤, 安徽农业科学, 2005, 33, 2334.)
[44] Liao, Q.-F.; Xie, S.-P.; Chen, X.-H.; Bi, K.-S. Trad. Chin. Drug Res. Clin. Pharm. 2006, 17, 198 (in Chinese).
(廖琼峰, 谢社平, 陈晓辉, 毕开顺, 中药新药临床药理, 2006, 17, 198.)
[45] Ouyang, F.; Liu, Y.; Xiao, H.-H.; Yu, H. Y.; Wang, N.-L.; Yao, X.-S. Chin. J. China Meter. Med. 2009, 34, 1225 (in Chinese).
(欧阳富, 刘远, 肖辉辉, 于海洋, 王乃利, 姚新生, 中国中药杂志, 2009, 34, 1225.)
[46] Yang, X.-J.; Wang, M.-S.; Wang, N.-L.; Chan, S.-C.; Yao, X.-S. J. Asian Nat. Prod. Res. 2007, 9, 583.
[47] Jutiviboonsuk, A.; Zhang, H. J.; Tan, G. T.; Ma, C. Y.; Hung, N. V.; Cuong, N. M.; Bunyapraphatsara, N.; Soejarto, D. D.; Fong, H. H. S. Phytochemistry 2005, 66, 2745.
[48] Kanchanapoom, T.; Noiarsa, P.; Otsuka, H.; Ruchirawat, S. Phytochemistry 2006, 67, 516.
[49] Buhrmester, R. A.; Eblingerla, J. E.; Seigler, D. S. Biochem. Syst. Ecol. 2000, 28, 689.
[50] DellaGreca, M.; Fiorentino, A.; Monaco, P.; Provitera, L.; Simonet, A. M. Nat. Prod. Lett. 2000, 14, 175.
[51] Jiang, D.-S.; Pei, G.; Zhou, P.-H.; Peng, X.-Y. J. Chin. Med. Mater. 2003, 26, 102 (in Chinese).
(蒋道松, 裴刚, 周朴华, 彭晓英, 中药材, 2003, 26, 102.)
[52] Panda, S.; Jafri, M.; Kar, A.; Meheta, B. K. Fitoterapia 2009, 80, 123.
[53] Lin, F.-G.; Sun, G.-R.; Liu, J.-H. Resour. Sci. 1996, 4, 45 (in Chinese).
(林风国, 孙广仁, 刘继宏, 资源科学, 1996, 4, 45.)
[54] Zakay-Rones, Z.; Thom, E.; Wollan, T.; Wadstein, J. Int. Med. Res. 2004, 32, 132140.
[55] Ahmadiani, A.; Fereidoni, M.; Semnania, S. J. Ethnopharmacol. 1998, 61, 229.
[56] Anon. Altern. Med. Rev. 2005, 10, 51.
[57] Morag, A. M.; Mumcuoglu, M.; Baybikov, T. A. Physiotherapy 1997, 25, 97.
[58] Mlinaric, A.; Kreft, S.; Umek, A. Pharmazie 2000, 55, 75.
[59] Yesilada, E.; Gurbuz, I.; Shibata, H. J. Ethnopharmacol. 1999, 66, 289.
[60] Cáceres, A.; López, B. R.; Giron, M. A. G. J. Ethnopharmacol. 1991, 31, 263.