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有机化学
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有机化学 ›› 2001, Vol. 21 ›› Issue (12): 1161-1163. 上一篇    下一篇

研究论文

对Niementowski反应的改进

刘志红;孙晓莉;张生勇   

  1. 第四军医大学化学教研室.
  • 发布日期:2001-12-25

An improved niementowski reaction

Liu Zhihong;Sun Xiaoli;Zhang Shengyong   

  1. Univ of No.4 Military Medicine, Teach Lab of Chem.
  • Published:2001-12-25

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547

被引次数

19

在三氯氧磷存在下，以甲酰胺和邻氨基苯甲酸类化合物为原料，用改进的Niementowski反应合成了5种喹唑啉酮化合物：6-X-4(3H)-喹唑啉酮(X=NO2,Cl,Br,I)和1-(呋喃-2-甲基)-6-磺酰胺基-7-氯-4(1H)-喹唑啉酮，并对该反应的历程进行了初步探讨。

关键词: 合成, 三氯氧磷, 邻氨基苯甲酸P, 反应机理, 甲酰胺, 喹唑啉酮P

Five quinazolinone compounds, such as 6-X-4(3H)-quinazolinone(X=NO2, Cl, Br, I) and 1-furfuryl-6-sulfamide-7-chloro-4(1H)-quinazolinone, were synthesized by reaction of anthranilic acids with formamide in presence of phosphoryl chloride. The mechanism of this reaction was also studied.

Key words: SYNTHESIS, PHOSPHORUS OXYCHLORIDE, O-AMINOBENZOIC ACID P, REACTION MECHANISM, FORMAMIDE, QUINAZOLINONE P

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