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有机化学
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有机化学 ›› 2003, Vol. 23 ›› Issue (5): 456-460. 上一篇    下一篇

研究论文

3-(D-葡萄糖-1-基)-6-芳基-7H-1，2，4-三唑并[3，4-b][1，3，4]噻二嗪类化合物的合成及波谱研究

张安将;张力学;熊轶;徐端均;李贤均   

  1. 四川大学化学系;温州师范学院药物研究所;浙江大学化学系
  • 发布日期:2003-05-25

Synthesis and NMR study of 6-Aryl-3-(D-gluco-pentitol-1-yl)-7H-1,2, 4-triazolo[3,4-b][1,3,4]thiadiazines

Zhang Anjiang;Zhang Lixue;Xiong Yi;Xu Duanjun;Li Xianjun   

  1. Department of Chemistry,Sichuan University;Institute of Pharmacy, Wenzhou Normal College;Departemnt of Chemistry,Zhejiang University
  • Published:2003-05-25

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ω-溴代芳香基乙酮与3-(D-葡萄糖-1-基)-4-氨基-5-巯基-1，2，4-三唑反应 合成了一系列新颖的3-(D-葡萄糖-1-基)-6-芳基-7H-1，2，4三唑并[3，4-b[1，3 ，4]噻二嗪．用元素分析，IR，NMR，MS对其结构进行了表征，研究了其NMR波谱特 征，并以^1H-^1H COSY，^13C-^1H COSY，COLOC二维NMR技术对其^1H NMR，^13C NMR的谱峰进行了全归属

关键词: 葡萄糖, 三唑 P, 噻二嗪 P, 质子磁共振谱法, 结构表征, 碳十三核磁共振谱法

Seven 6-aryl-3-(D-gluco-pentitol-l-yl)-7H-l,2,4-triazolo[3,4-b] [l, 3,4]thiadiazines were synthesized in high yields by the reaction of 4- amino-5-mercapto-3-( D-gluco-pentitol-l-yl)-l,2,4-triazole with substituted w-bromoacetophenones. Their structures were confirmed by elemental analysis, IR, NMR and MS spectra. The NMR characteristics of the title compounds were further elucidated with ID and 2D NMR techniques

Key words: GLUCOSE;PYRRODIAZOLE P;THIADIAZINE P;1HNMR;STRUCTURE CHARACTERISTICS, C13NMR

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