关键词: 脱镁叶绿酸-a甲酯, 红紫素-18甲酯, 光敏剂, 可见光谱, 光动力疗法

Methyl pheophorbide-a was used as a starting material for modifications at 3-position and transformation on E-ring. The introduction of biphenylyloxy was performed by addition of HBr and nucleophilic substitution with phenylphenol on vinyl group at 3-position. In basic condition E-ring was converted into the cyclohexanedicarboxylic anhydride to form purpurin-18 derivatives by the air-oxidation. The oxidized products were reacted with hydroxylamine hydrochloride to generate purpurin-18 imide by ammonolysis andrecondensation. The alkylation and acylation for hydroxyl group linked with nitrogen were accomplished to give N-alkoxy and N-acyloxy purpurin-18 imides, respectively. The effect on their visible spectra by variation of chemicalconstruction was discussed. The structures of all new compounds were characterized by elemental analysis, UV, IR and ¹H NMR spectra.

Key words: methyl pheophorbide-a, purpurin-18 methyl ester, photosensitizer, visible spectra, photodynamic therapy