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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (3): 306-309. 上一篇    下一篇

研究简报

气相色谱法手性拆分氯代和溴代环氧苯乙烷

董晓渭a, 许旭*,a, 金浩b, 李祖义b   

  1. a 中国科学院上海有机化学研究所金属有机化学国家重点实验室 上海 200032
    b 中国科学院上海有机化学研究所生命有机化学国家重点实验室 上海 200032
  • 收稿日期:2003-04-03 修回日期:2003-07-16 接受日期:2003-09-05 发布日期:2022-09-20
  • 基金资助:
    湖北教育厅科学基金(No. 2001A41007)重点资助项目

Separation of Chloro-substituted and Bromo-substituted Styrene Oxide by Chiral GC

DONG, Xiao-Weia, XU, Xu*,a, JIN, Haob, LI, Zu-Yib   

  1. a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
    b State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2003-04-03 Revised:2003-07-16 Accepted:2003-09-05 Published:2022-09-20
  • Contact: *E-mail: lxli@jznu.net

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用手性毛细管气相色谱法(使用2,6-戊基-3-丙基-γ-环糊精柱,Chiraldex G-PN)对3种溴代环氧苯乙烷和3种氯代环氧苯乙烷对映体进行了拆分.初步讨论了对映体在该手性毛细管柱上的保留行为.已用于此类化合物对映体过量值(ee值)的测定.

关键词: 毛细管气相色谱法, 手性拆分, 环糊精固定相, 氯代环氧苯乙烷, 溴代环氧苯乙烷

Three chloro-substituted and threebromo-substituted styrene oxides were separated by gas chromatography using thechiral capillary column of Chiraldex G-PN. According to the results, the enantiomer with lower capacity factor (k′) showed larger separation factor (α′) and better resolution. It suggests that the interaction between sample andimmobile phase (include dilutent) contains chiral and achiral parts: chiral separation results from chiral interaction, and achiral interaction affects retention behavior of samples. The method has been used for determining the ee value of optically active styrene oxides.

Key words: capillary gas chromatography, chiral separation, cyclodextrin chiral selector, chloro-substituted styrene oxide, bromo-substituted styrene oxide