有机化学 ›› 2005, Vol. 25 ›› Issue (10): 1294-1297. 上一篇    下一篇

研究简报

微波辐射下一步合成9-芳基-1,2,3,4,5,6,7,8,9,10-十氢-1,8-吖啶二酮

华国平1,2,李团结2,邹翔2,屠树江*,2
朱松磊2,章晓镜2,纪顺俊3,张勇3   

  1. (1徐州建筑职业技术学院 徐州 221008)
    (2徐州师范大学化学系 江苏省药用植物生物技术重点实验室 徐州221009)
    (3苏州大学化学化工学院 苏州 215006)
  • 收稿日期:2004-12-08 修回日期:2005-04-26 发布日期:2005-10-08
  • 通讯作者: 屠树江

One-pot Synthesis of 9-Aryl-1,2,3,4,5,6,7,8,9,10-decahydro- 1,8-acridinedione under Microwave Irradiation

HUA Guo-Ping1,2,LI Tuan-Jie2,ZOU Xiang2,TU Shu-Jiang*,2,ZHU Song-Lei2,ZHANG Xiao-Jing2,JI Shui-Jun3,ZHANG Yong3   

  1. (1 Xuzhou Institute of Architectural Technology, Xuzhou 221008)
    (2 Key Laboratory of Biotechnology on Medical Plant of Jiangsu, Department of Chemistry,
    Xuzhou Normal University, Xuzhou 221009)
    (3 College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006)
  • Received:2004-12-08 Revised:2005-04-26 Published:2005-10-08
  • Contact: TU Shu-Jiang

以芳醛、1,3-环己二酮、醋酸铵为原料在无溶剂条件下经微波辐射合成了一系列9-芳基-1,2,3,4,5,6,7,8,9,10-十 氢-1,8-吖啶二酮. 该反应的反应时间短、产率高、环境友好、后处理方便. 产物的结构经红外光谱、核磁共振谱表征, 3d的结构经单晶X射线衍射进一步确证.

关键词: 芳醛, 1,3-环己二酮, 吖啶二酮, 微波辐射

A series of 9-aryl-1,2,3,4,5,6,7,8,9,10-decahydro-1,8-acridinedione derivatives were synthesized via the reaction of aromatic aldehydes with 1,3-cyclohexanedione and ammonium acetate in solvent-free conditions under microwave irradiation by one-pot reaction. The reaction easily could be worked up with short reaction time, high yields and environmental friendliness. The structures of the products were confirmed by IR and 1H NMR spectra. The structure of 3d was further determined by X-ray analysis.

Key words: microwave irradiation, acridinedione, 1,3-cyclohexanedione, aromatic aldehyde