SIOC English
有机化学
高级检索

有机化学 ›› 2005, Vol. 25 ›› Issue (10): 1298-1301. 上一篇    下一篇

研究简报

二(三甲硅亚甲基)锡二芳香羧酸酯的合成和结构表征

林森*,1,2，邓瑞红2，卢志强2
孙小强1,3，汪信1，陆路德1   

  1. (1南京理工大学化工学院 南京 210094)
    (2南昌大学化学系 南昌 330047)
    (3江苏工业学院 常州 213016)
  • 收稿日期:2004-11-13 修回日期:2005-04-28 发布日期:2005-10-08
  • 通讯作者: 林森

Synthesis and Characterization of Bis[(trimethylsilyl)methyl]tin Arylcarboxylates

LIN Sen*,1,2,DENG Rui-Hong2,LU Zhi-Qiang2
SUN Xiao-Qiang1,3,WANG Xin1,LU Lu-De1   

  1. (1 School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094)
    (2 Department of Chemistry, Nanchang University, Nanchang 330047)
    (3 Jiangsu Polytechnic University, Changzhou 213016)
  • Received:2004-11-13 Revised:2005-04-28 Published:2005-10-08
  • Contact: LIN Sen

PDF

1432

用二(三甲硅亚甲基)二氯化锡与芳香酸按1∶2的摩尔比进行反应, 合成了11个新的含硅有机锡化合物二(三甲硅亚甲基)锡二芳香羧酸酯. 通过IR, 1H NMR, 13C NMR, MS以及元素分析对这些化合物的结构进行了表征. 部分化合物生物活性的初步测定结果表明, 该类化合物对肺癌细胞SPC-A-1具有较好的体外抗癌活性.

关键词: 含硅有机锡化合物, 合成, 结构表征, 抗癌活性

Eleven bis[(trimethylsilyl)methyl]tin arylcarboxylates have been synthesized by the reaction of bis[(trimethylsilyl)methyl]tin dichloride with arylcarboxylic acids, and characterized by IR, 1H NMR, 13C NMR, MS spectra and elemental analysis. The preliminary bioassay tests showed that they have a good antitumour activity in vitro against tumour cells SPC-A-1.

Key words: synthesis, structural analysis, antitumour activity, organotin compound containing silicon